US 11,981,686 B2
Urea compound having substituent
Junya Kawai, Tokyo (JP); Osamu Iwamoto, Tokyo (JP); Yuma Umezaki, Tokyo (JP); Katsuyoshi Nakajima, Tokyo (JP); Hiroyuki Tsuruoka, Tokyo (JP); Keiji Saito, Tokyo (JP); Nobuya Kurikawa, Tokyo (JP); Natsumi Nishihama, Tokyo (JP); Shinji Tanaka, Tokyo (JP); Momoko Ogitani, Tokyo (JP); Tomohiro Honda, Tokyo (JP); Wataru Saitoh, Tokyo (JP); Tsuyoshi Soneda, Tokyo (JP); and Nobuyuki Ohkawa, Tokyo (JP)
Assigned to DAIICHI SANKYO COMPANY, LIMITED, Tokyo (JP)
Appl. No. 17/425,520
Filed by DAIICHI SANKYO COMPANY, LIMITED, Tokyo (JP)
PCT Filed Jan. 23, 2020, PCT No. PCT/JP2020/002351
§ 371(c)(1), (2) Date Jul. 23, 2021,
PCT Pub. No. WO2020/153433, PCT Pub. Date Jul. 30, 2020.
Claims priority of application No. 2019-010252 (JP), filed on Jan. 24, 2019.
Prior Publication US 2023/0058950 A1, Feb. 23, 2023
Int. Cl. C07D 513/18 (2006.01); C07D 513/04 (2006.01)
CPC C07D 513/18 (2013.01) [C07D 513/04 (2013.01)] 14 Claims
 
1. A compound represented by Formula (1) or a pharmaceutically acceptable salt thereof,

OG Complex Work Unit Chemistry
wherein the symbols in Formula (1) have the following definitions,
R1 and R2 independently represent a hydrogen atom or a C1-C6 alkyl group and may be the same or different from each other, or R1 and R2 bond to each other to form a substituent and the substituent represents a group selected from the group consisting of

OG Complex Work Unit Chemistry
R12 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkylcarbonyl group, a C1-C6 alkoxycarbonyl group, or a C1-C6 alkylsulfonyl group,
R3 represents a hydrogen atom or a C1-C6 alkyl group,
R6 represents a C1-C6 alkyl group that may be substituted with one to three groups selected from a group G, a C3-C6 cycloalkyl group that may be substituted with one or two groups selected from the group G, and a 4- to 7-membered heterocyclic group that may be substituted with one or two groups selected from the group G,
the group G consists of substituents selected from the group consisting of a hydroxyl group, a halogen atom, an amino group, a halo-C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, an amino C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfonyl group, a hydroxy C1-C6 alkoxy group, a C1-C6 alkylcarbonyl group, a carbamoyl group that may be substituted with one or two groups selected from a group J, a C3-C6 cycloalkyl group that may be substituted with one or two groups selected from the group J, a 4- to 7-membered heterocyclic group that may be substituted with one or two groups selected from the group J, and a 5- to 6-membered heteroaryl group that may be substituted with one or two groups selected from the group J,
the group J consists of substituents selected from the group consisting of a hydroxyl group, an oxo group, an amino C1-C6 alkyl group, an amino group, a C1-C6 alkyl group, and a C1-C6 alkylcarbonyl group,
R7 represents a hydrogen atom, or
R6 and R7 bond to each other to form a substituent and the substituent represents a group shown below,

OG Complex Work Unit Chemistry
the group is oriented in either a rightward or leftward direction,
R67-1 and R67-2 independently represent a hydrogen atom, a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C4 alkylene group, or a C1-C6 alkoxy C1-C6 alkyl group and may be the same or different from each other,

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
wherein Q is a substituent selected from the group consisting of a C3-C6 cycloalkyl group that is substituted with any of one to three groups selected from RQ4, a phenyl group that is substituted with any of one to three groups selected from RQ4, a pyridyl group that is substituted with any of one to three groups selected from RQ4, and a 1,3-benzoxazol-2-yl group that is substituted any of one to three groups selected from RQ4, and
RQ4 represents a halogen atom, a cyano group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkyl group, a halo-C1-C6 alkoxy group, a C1-C6 alkylsulfonyl group, a di-C1-C6 alkylamino group, or a C3-C6 cycloalkylcarbonyl group,
and
Y represents a group selected from the group consisting of or a single bond,

OG Complex Work Unit Chemistry
wherein the groups are oriented in either a rightward or leftward direction,
RY1 represents a hydrogen atom or a C1-C6 alkyl group, and
the following compounds or pharmaceutically acceptable salts thereof are excluded

OG Complex Work Unit Chemistry