US 11,981,684 B2
Macrocyclic compounds and uses thereof
Jingrong Jean Cui, San Diego, CA (US); Evan W. Rogers, San Diego, CA (US); Jane Ung, San Diego, CA (US); Jeffrey Whitten, San Diego, CA (US); Dayong Zhai, San Diego, CA (US); Wei Deng, San Diego, CA (US); Xin Zhang, San Diego, CA (US); Zhongdong Huang, San Diego, CA (US); Jing Liu, San Diego, CA (US); and Han Zhang, San Diego, CA (US)
Assigned to TURNING POINT THERAPEUTICS, INC., San Diego, CA (US)
Filed by TURNING POINT THERAPEUTICS, INC., San Diego, CA (US)
Filed on Feb. 22, 2022, as Appl. No. 17/676,942.
Application 17/676,942 is a continuation of application No. 16/634,289, granted, now 11,286,264, previously published as PCT/US2018/043817, filed on Jul. 26, 2018.
Claims priority of provisional application 62/700,990, filed on Jul. 20, 2018.
Claims priority of provisional application 62/538,193, filed on Jul. 28, 2017.
Prior Publication US 2022/0324879 A1, Oct. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 498/16 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01)
CPC C07D 498/16 (2013.01) [A61P 35/00 (2018.01); C07K 16/2863 (2013.01); A61K 45/06 (2013.01)] 20 Claims
 
1. A method of treating a solid cancer in a patient in need thereof, comprising administering a therapeutically effective amount of a compound:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.