US 11,981,677 B2
Further substituted triazolo quinoxaline derivatives
Florian Jakob, Aachen (DE); Jo Alen, Miermaal (BE); Simon Lucas, Bad König (DE); Tobias Craan, Niedernberg (DE); Ingo Konetzki, Monschau (DE); Achim Kless, Aachen (DE); Stefan Schunk, Aachen (DE); Paul Ratcliffe, Aachen (DE); Sebastian Wachten, Aachen (DE); and Simon Cruwys, Aachen (DE)
Assigned to Grünenthal GmbH, Aachen (DE)
Filed by Grünenthal GmbH, Aachen (DE)
Filed on Feb. 9, 2021, as Appl. No. 17/171,520.
Application 17/171,520 is a continuation of application No. 16/517,080, filed on Jul. 19, 2019, granted, now 10,981,918.
Claims priority of application No. 18184607 (EP), filed on Jul. 20, 2018.
Prior Publication US 2021/0163491 A1, Jun. 3, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 487/04 (2006.01)
CPC C07D 487/04 (2013.01) 15 Claims
 
1. A compound according to general formula (I),

OG Complex Work Unit Chemistry
wherein
R1 represents H, an alkyl, cycloalkyl, heteroaryl, or hetero-cycloalkyl group;
either of R2 and R3 represents H; F; Cl; Br; I; one or more amino-, cyano-, alkyl-, and cycloalkyl groups;
R4 represents F or Cl;
R5 and R6 represent independently from one another H or unsubstituted C1-4-alkyl;
X represents N or NR7;
Z represents N, NR7 or CR9;
R7 represents H or L-R8; wherein
L represents bond; S(O); S(O)2; C1-6-alkylene; C(O); C1-6-alkylene-C(O); C(O)—O; C1-6-alkylene-C(O)—O; C1-6-alkylene-N(H)—C(O); C1-6-alkylene-N(C1-10-alkyl)-C(O); C1-6-alkylene-N(H)—C(O)—O; C1-6-alkylene-N(C1-10-alkyl)-C(O)—O; O; NH or N(C1-10-alkyl);
R8 represents an alkyl, cycloalkyl, heteroaryl, or hetero-cycloalkyl group;
R9 and R10 represent independently from one another H; F; Cl; Br; I; one or more amino-, cyano-, sulfonyl-, phosphoryl-, alkyl-, cycloalkyl-, and hetero-cycloalkyl groups;
R11 represents F; Cl; Br; I; one or more of amino-, cyano-, sulfonyl-, phosphoryl-, alkyl-, cycloalkyl-, and hetero-cycloalkyl groups;
n represents 0, 1, 2 or 3;
in the form of the free compound or a physiologically acceptable salt thereof.