US 11,981,667 B2
Sulfonamide carboxamide compounds
Matthew Cooper, Cambridge (GB); David Miller, Cambridge (GB); Angus MacLeod, Cambridge (GB); Jimmy Van Wiltenburg, Groningen (NL); Stephen Thom, Nottingham (GB); Stephen St-Gallay, Nottingham (GB); and Jonathan Shannon, Nottingham (GB)
Assigned to INFLAZOME LIMITED, Dublin (IE)
Filed by INFLAZOME LIMITED, Dublin (IE)
Filed on Aug. 16, 2022, as Appl. No. 17/889,300.
Application 17/889,300 is a continuation of application No. 16/629,006, granted, now 11,465,992, previously published as PCT/EP2018/068077, filed on Jul. 4, 2018.
Claims priority of application No. 1710943 (GB), filed on Jul. 7, 2017; application No. 1713079 (GB), filed on Aug. 15, 2017; application No. 1713082 (GB), filed on Aug. 15, 2017; application No. 1718561 (GB), filed on Nov. 9, 2017; application No. 1718563 (GB), filed on Nov. 9, 2017; and application No. 1721726 (GB), filed on Dec. 22, 2017.
Prior Publication US 2023/0037255 A1, Feb. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 409/04 (2006.01); C07D 205/04 (2006.01); C07D 205/12 (2006.01); C07D 207/12 (2006.01); C07D 211/54 (2006.01); C07D 211/96 (2006.01); C07D 215/36 (2006.01); C07D 223/06 (2006.01); C07D 239/60 (2006.01); C07D 241/18 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 453/02 (2006.01); C07D 471/08 (2006.01)
CPC C07D 409/04 (2013.01) [C07D 205/04 (2013.01); C07D 205/12 (2013.01); C07D 207/12 (2013.01); C07D 211/54 (2013.01); C07D 211/96 (2013.01); C07D 215/36 (2013.01); C07D 223/06 (2013.01); C07D 239/60 (2013.01); C07D 241/18 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01)] 8 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Q is O;
R1 is a non-aromatic heterocyclic group selected from:

OG Complex Work Unit Chemistry
wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 is optionally substituted with one or more substituents independently selected from halo; —CN; —NO2; —N3; —Rβ; —OH; —ORβ; —SH; —SRβ; —SO2Rβ; —NH2; —NHRβ; —N(Rβ)2; —CHO; —CORβ; —COOH; —COORβ; —OCORβ; —Rα—CHO; —Rα—CORβ; —Rα—COOH; —Rα—COORβ; —Rα—OCORβ; —NH—CHO; —NRβ—CHO; —NH—CORβ; —NRβ—CORβ; —CONH2; —CONHRβ; —CON(Rβ)2; —Rα—NH—CHO; —Rα—NRβ—CHO; —Rα—NH—CORβ; —Rα—NRβ—CORβ; —Rα—CONH2; —Rα—CONHRβ; —Rα—CON(Rβ)2; a C3-C7 cycloalkyl group optionally substituted with one or more C1-C3 alkyl or C1-C3 haloalkyl groups; a C3-C7 cycloalkenyl group optionally substituted with one or more C1-C3 alkyl or C1-C3 haloalkyl groups;

OG Complex Work Unit Chemistry
oxo (═O); or a C1-C4 alkylene bridge;
each —Rα— is independently selected from an alkylene, alkenylene or alkynylene group, wherein the alkylene, alkenylene or alkynylene group contains from 1 to 6 carbon atoms in its backbone, and wherein the alkylene, alkenylene or alkynylene group is optionally substituted with one or more halo and/or —Rβ groups;
each —Rβ is independently selected from a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C2-C6 cyclic group, and wherein any —Rβ is optionally substituted with one or more C1-C3 alkyl, C1-C3 haloalkyl, C3-C7 cycloalkyl, —O(C1-C3 alkyl), halo, —CN, —C≡CH or oxo (═O) groups;
each —Rβ is independently selected from a C1-C6 alkyl or C1-C3 haloalkyl group;
each m is independently selected from 1, 2 or 3;
each n is independently selected from 1, 2 or 3; and
R2 is:

OG Complex Work Unit Chemistry