CPC C07D 409/04 (2013.01) [C07D 205/04 (2013.01); C07D 205/12 (2013.01); C07D 207/12 (2013.01); C07D 211/54 (2013.01); C07D 211/96 (2013.01); C07D 215/36 (2013.01); C07D 223/06 (2013.01); C07D 239/60 (2013.01); C07D 241/18 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01)] | 8 Claims |
1. A compound of formula (I):
![]() or a pharmaceutically acceptable salt or solvate thereof, wherein:
Q is O;
R1 is a non-aromatic heterocyclic group selected from:
![]() wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 is optionally substituted with one or more substituents independently selected from halo; —CN; —NO2; —N3; —Rβ; —OH; —ORβ; —SH; —SRβ; —SO2Rβ; —NH2; —NHRβ; —N(Rβ)2; —CHO; —CORβ; —COOH; —COORβ; —OCORβ; —Rα—CHO; —Rα—CORβ; —Rα—COOH; —Rα—COORβ; —Rα—OCORβ; —NH—CHO; —NRβ—CHO; —NH—CORβ; —NRβ—CORβ; —CONH2; —CONHRβ; —CON(Rβ)2; —Rα—NH—CHO; —Rα—NRβ—CHO; —Rα—NH—CORβ; —Rα—NRβ—CORβ; —Rα—CONH2; —Rα—CONHRβ; —Rα—CON(Rβ)2; a C3-C7 cycloalkyl group optionally substituted with one or more C1-C3 alkyl or C1-C3 haloalkyl groups; a C3-C7 cycloalkenyl group optionally substituted with one or more C1-C3 alkyl or C1-C3 haloalkyl groups;
![]() oxo (═O); or a C1-C4 alkylene bridge;
each —Rα— is independently selected from an alkylene, alkenylene or alkynylene group, wherein the alkylene, alkenylene or alkynylene group contains from 1 to 6 carbon atoms in its backbone, and wherein the alkylene, alkenylene or alkynylene group is optionally substituted with one or more halo and/or —Rβ groups;
each —Rβ is independently selected from a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C2-C6 cyclic group, and wherein any —Rβ is optionally substituted with one or more C1-C3 alkyl, C1-C3 haloalkyl, C3-C7 cycloalkyl, —O(C1-C3 alkyl), halo, —CN, —C≡CH or oxo (═O) groups;
each —Rβ is independently selected from a C1-C6 alkyl or C1-C3 haloalkyl group;
each m is independently selected from 1, 2 or 3;
each n is independently selected from 1, 2 or 3; and
R2 is:
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