US 11,981,666 B2
GLP-1 receptor agonist and composition and use thereof
Wenqiang Zhai, Zhejiang (CN); Zhimin Zhang, Zhejiang (CN); Zhe Wang, Zhejiang (CN); Hao Pan, Zhejiang (CN); Liubin Guo, Zhejiang (CN); and Qian Wang, Zhejiang (CN)
Assigned to HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD., Zhejiang (CN)
Filed by HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD., Zhejiang (CN)
Filed on Sep. 13, 2023, as Appl. No. 18/367,517.
Application 18/367,517 is a continuation of application No. PCT/CN2022/100685, filed on Jun. 23, 2022.
Claims priority of application No. 202110702643.0 (CN), filed on Jun. 24, 2021.
Prior Publication US 2024/0116906 A1, Apr. 11, 2024
Int. Cl. C07D 405/14 (2006.01)
CPC C07D 405/14 (2013.01) 12 Claims
 
1. A compound having a structure of Formula II-4:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y1 is N;

OG Complex Work Unit Chemistry
m is 0;
R4 is hydrogen;
R1 is selected from halogen; and
R0 is hydrogen.