US 11,981,664 B2
Photoresponsive nutlin derivatives and uses thereof
Mickel Jens Hansen, Eext (NL); Bernard Lucas Feringa, Paterswolde (NL); and Femke Maria Feringa, Amsterdam (NL)
Assigned to Rijksuniversiteit Groningen, Groningen (NL); and Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, Amsterdam (NL)
Appl. No. 17/282,274
Filed by Rijksuniversiteit Groningen, Groningen (NL); and Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, Amsterdam (NL)
PCT Filed Oct. 2, 2019, PCT No. PCT/NL2019/050659
§ 371(c)(1), (2) Date Apr. 1, 2021,
PCT Pub. No. WO2020/071911, PCT Pub. Date Apr. 9, 2020.
Claims priority of application No. 18198468 (EP), filed on Oct. 3, 2018.
Prior Publication US 2021/0371406 A1, Dec. 2, 2021
Int. Cl. C07D 405/12 (2006.01); A61K 41/00 (2020.01)
CPC C07D 405/12 (2013.01) [A61K 41/0042 (2013.01)] 27 Claims
 
1. A compound having the chemical structure

OG Complex Work Unit Chemistry
wherein
V is —H or —F;
W is —F, —Cl or —Br;
X is selected from the group consisting of H, F, Cl, Br, I, cyano, nitro, ethynyl, cyclopropyl, methyl, ethyl, isopropyl, vinyl and methoxy;
Y is independently selected from the group consisting of —H, —F, —Cl, —Br, —I, —CN, —OH, nitro, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl and lower alkynyl;
Z is Cl, F, Br, I or lower alkoxy;
R1 is —H or —CH3
R2 is 0, S or C(CN)2
or a pharmaceutically acceptable salt thereof.