	US 11,980,654 B2
	Method to inhibit neutrophil recruitment to damaged tissue using myeloid-derived growth factor
Anna Huttenlocher, Madison, WI (US); Deane Mosher, Madison, WI (US); Valeriu Bortnov, Madison, WI (US); David Bennin, Madison, WI (US); Ruth Anne Houseright, Madison, WI (US); and Frances M Smith, Madison, WI (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed on Sep. 22, 2021, as Appl. No. 17/481,490.
Claims priority of provisional application 63/081,664, filed on Sep. 22, 2020.
Prior Publication US 2022/0168390 A1, Jun. 2, 2022
Int. Cl. A61K 38/18 (2006.01); A61P 17/02 (2006.01)

CPC A61K 38/18 (2013.01) [A61P 17/02 (2018.01)]

12 Claims

1. A method to inhibit neutrophil recruitment to damaged tissue in a subject in need thereof, the method comprising administering to a subject having neutrophil recruitment to a wound and/or a burn at a site on the subject, an effective amount of a myeloid-derived growth factor (“MYDGF”) peptide selected from the group consisting of the amino acid sequence of SEQ ID NOS: 1, 3, or 7, or a pharmaceutically suitable salt of any of the foregoing, wherein the amount is effective to inhibit neutrophil recruitment to the wound and/or burn site.