US 11,980,647 B2
Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause
Eric Michael Schott, Boston, MA (US); Gerardo V. Toledo, Hopkinton, MA (US); and Maria Juliana Soto-Giron, Cambridge, MA (US)
Assigned to SOLAREA BIO, INC., Cambridge, MA (US)
Filed by Solarea Bio, Inc., Cambridge, MA (US)
Filed on Nov. 7, 2022, as Appl. No. 18/053,262.
Application 18/053,262 is a continuation in part of application No. 16/694,876, filed on Nov. 25, 2019, granted, now 11,819,524.
Application 16/694,876 is a continuation of application No. PCT/US2019/049823, filed on Sep. 5, 2019.
Claims priority of provisional application 63/282,155, filed on Nov. 22, 2021.
Claims priority of provisional application 62/863,722, filed on Jun. 19, 2019.
Claims priority of provisional application 62/728,018, filed on Sep. 6, 2018.
Claims priority of provisional application 62/728,019, filed on Sep. 6, 2018.
Claims priority of provisional application 62/728,020, filed on Sep. 6, 2018.
Claims priority of provisional application 62/727,503, filed on Sep. 5, 2018.
Prior Publication US 2023/0233625 A1, Jul. 27, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/741 (2015.01); A23L 33/00 (2016.01); A23L 33/105 (2016.01); A23L 33/125 (2016.01); A23L 33/135 (2016.01); A61K 9/00 (2006.01); A61K 31/702 (2006.01); A61K 35/747 (2015.01); A61K 36/062 (2006.01); A61K 36/45 (2006.01); A61K 47/12 (2006.01); A61P 15/12 (2006.01); A61P 19/10 (2006.01); A61K 35/00 (2006.01)
CPC A61K 35/747 (2013.01) [A23L 33/105 (2016.08); A23L 33/125 (2016.08); A23L 33/135 (2016.08); A23L 33/40 (2016.08); A61K 9/0053 (2013.01); A61K 31/702 (2013.01); A61K 36/062 (2013.01); A61K 36/45 (2013.01); A61K 47/12 (2013.01); A61P 15/12 (2018.01); A61P 19/10 (2018.01); A23V 2400/121 (2023.08); A23V 2400/169 (2023.08); A23V 2400/321 (2023.08); A61K 2035/115 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A dietary supplement comprising a combination of four heterologous microbes consisting of Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii, wherein the combination of four heterologous microbes comprises at least 1×10 7 of each of the four heterologous microbes, wherein each of the four heterologous microbes comprises a gene or gene pathway directed to biosynthesis of short chain fatty acid (SCFA) or metabolites thereof and wherein the combination produces an increased amount of SCFA when grown together relative to the summed amount of SCFA produced by an equivalent amount of each distinct microbe grown in isolation under the same conditions, wherein the combination lessens a decrease in, maintains, or improves bone health in a subject, and wherein the dietary supplement is formulated for oral delivery.