US 11,980,534 B2
Three-dimensional scaffolds, methods for fabricating the same, and methods of treating a peripheral nerve or spinal cord injury
Andres Hurtado, Baltimore, MD (US); Ryan James Gilbert, Houghton, MI (US); Han Bing Wang, Houghton, MI (US); Jared M. Cregg, Houghton, MI (US); Michael E. Mullins, Houghton, MI (US); and Martin Oudega, Munhall, PA (US)
Assigned to Rensselaer Polytechnic Institute, Troy, NY (US); and Johns Hopkins University, Baltimore, MD (US)
Filed by The Johns Hopkins University, Baltimore, MD (US); and Rensselaer Polytechnic Institute, Troy, NY (US)
Filed on Jul. 29, 2019, as Appl. No. 16/524,473.
Application 16/524,473 is a division of application No. 13/638,923, granted, now 10,413,391, previously published as PCT/US2011/030965, filed on Apr. 1, 2011.
Claims priority of provisional application 61/320,088, filed on Apr. 1, 2010.
Prior Publication US 2019/0350688 A1, Nov. 21, 2019
Int. Cl. A61F 2/00 (2006.01); A61L 27/18 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); D01D 5/00 (2006.01); D06M 16/00 (2006.01); A61F 2/04 (2013.01)
CPC A61F 2/00 (2013.01) [A61F 2/0063 (2013.01); A61L 27/18 (2013.01); A61L 27/383 (2013.01); A61L 27/3834 (2013.01); A61L 27/54 (2013.01); D01D 5/0076 (2013.01); D06M 16/003 (2013.01); A61F 2/04 (2013.01); A61L 2300/254 (2013.01); A61L 2300/414 (2013.01); A61L 2300/416 (2013.01); A61L 2430/32 (2013.01); A61L 2430/38 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for fabricating a three-dimensional scaffold, the method comprising:
electrospinning a plurality of fibers to produce at least one layer of highly-aligned fibers; and
forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers,
wherein the at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers,
wherein the at least one layer of highly-aligned fibers includes an outer profile and an inner profile, and
wherein the at least one layer of highly-aligned fibers is configured to be implanted into the body such that the outer profile is substantially circular, and wherein the inner profile is, when viewed in the general direction of the fibers, selected from the group consisting of: an S-shaped profile, an I-shaped profile, a W-shaped profile, a Z-shaped profile, and a helicoid.