	US 11,980,453 B2
	Interferometric technique for measuring cerebral blood flow using inexpensive CMOS sensors
Wenjun Zhou, Davis, CA (US); Oybek Kholiqov, Davis, CA (US); and Vivek Jay Srinivasan, Davis, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/046,246
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Apr. 15, 2019, PCT No. PCT/US2019/027546 § 371(c)(1), (2) Date Oct. 8, 2020, PCT Pub. No. WO2019/204231, PCT Pub. Date Oct. 24, 2019.
Claims priority of provisional application 62/658,442, filed on Apr. 16, 2018.
Prior Publication US 2021/0030284 A1, Feb. 4, 2021
Int. Cl. A61B 5/026 (2006.01); A61B 5/00 (2006.01)

CPC A61B 5/0261 (2013.01) [A61B 5/4064 (2013.01); A61B 2562/0238 (2013.01); A61B 2562/04 (2013.01)]

31 Claims

1. A method for non-invasively analyzing blood flow in a sample of living tissue, comprising:

obtaining narrow-band light from a temporally coherent source;

splitting the obtained narrow-band light between a reference path and a sample path;

multiply scattering light from the sample path by passing the light through the sample;

recombining light from the reference path and the multiply scattered light from the sample path;

using a sensor array to detect an interference pattern resulting from the recombination; and

analyzing signals from the sensor array to determine a blood flow in the sample.