US 11,980,427 B2
Brain navigation methods and device
Hagai Bergman, Jerusalem (IL); Omer Naor, Kiryat-Tivon (IL); Jubran Elfar, Nazareth (IL); Imad Younis, Nazareth Ilit (IL); Adi Balan, Haifa (IL); Zvi Israel, Jerusalem (IL); Dan Valsky, Beer-Sheva (IL); Odeya Marmor, Ramla (IL); Renana Eitan, Jerusalem (IL); John Rizik, Kfar-Reine (IL); Majd Sleem, Nazareth Ilit (IL); Paul Mcsherry, Woodbury, MN (US); Steven Scott, Excelsior, MN (US); and Benjamin Matter, Ham Lake, MN (US)
Assigned to Alpha Omega Engineering Ltd., Nof HaGalil (IL)
Filed by Alpha Omega Engineering Ltd., Nof HaGalil (IL)
Filed on May 26, 2021, as Appl. No. 17/330,540.
Application 17/330,540 is a continuation of application No. 16/315,714, granted, now 11,051,889, previously published as PCT/IL2017/050763, filed on Jul. 7, 2017.
Application 16/315,714 is a continuation in part of application No. PCT/IL2017/050328, filed on Mar. 14, 2017.
Application PCT/IL2017/050328 is a continuation in part of application No. PCT/US2016/031448, filed on May 9, 2016.
Claims priority of provisional application 62/459,415, filed on Feb. 15, 2017.
Claims priority of provisional application 62/459,422, filed on Feb. 15, 2017.
Claims priority of provisional application 62/370,806, filed on Aug. 4, 2016.
Claims priority of provisional application 62/359,615, filed on Jul. 7, 2016.
Claims priority of provisional application 62/307,835, filed on Mar. 14, 2016.
Claims priority of provisional application 62/159,336, filed on May 10, 2015.
Prior Publication US 2021/0282869 A1, Sep. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 34/20 (2016.01); A61N 1/05 (2006.01); A61B 5/24 (2021.01); A61B 34/10 (2016.01)
CPC A61B 34/20 (2016.02) [A61N 1/0534 (2013.01); A61N 1/0551 (2013.01); A61B 5/24 (2021.01); A61B 2034/107 (2016.02); A61B 2034/2053 (2016.02); A61B 2034/2065 (2016.02)] 22 Claims
OG exemplary drawing
 
1. A method for navigating an electrical lead having at least two electrodes to a selected brain target, comprising:
advancing an electrical lead comprising at least two electrodes through brain tissue along a selected insertion trajectory;
recording differential electrical signals by said at least two electrodes during said advancing;
analyzing said recorded differential electrical signals using stored reference indications of electrical signals associated with tissue along said insertion trajectory;
estimating proximity between a distal end of said electrical lead to said selected brain target based on results of said analyzing.