US 12,298,233 B2
Method and analyzer to correct for unknown interferences in a patient blood sample
Jeffrey R. Jasperse, Newton, MA (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Appl. No. 18/000,938
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
PCT Filed Jun. 9, 2021, PCT No. PCT/US2021/036515
§ 371(c)(1), (2) Date Dec. 7, 2022,
PCT Pub. No. WO2021/252564, PCT Pub. Date Dec. 16, 2021.
Claims priority of provisional application 63/037,767, filed on Jun. 11, 2020.
Prior Publication US 2023/0221244 A1, Jul. 13, 2023
Int. Cl. G01N 21/31 (2006.01); G01N 1/40 (2006.01); G01N 33/49 (2006.01); G01N 33/72 (2006.01); G01N 15/01 (2024.01)
CPC G01N 21/31 (2013.01) [G01N 1/4077 (2013.01); G01N 33/491 (2013.01); G01N 33/721 (2013.01); G01N 2015/011 (2024.01)] 17 Claims
OG exemplary drawing
 
1. A blood analyzer, comprising:
a housing assembly that defines an internal space;
a light source mounted to the housing assembly in the internal space, the light source configured to generate an optical signal having wavelengths spanning a range from 450 nm to 680 nm, the optical signal being transmitted through a path;
a detector within the path of the optical signal, the detector configured to generate data indicative of intensity of the optical signal at wavelengths within the range;
a transparent sample vessel positioned within the path between the light source and the detector such that the optical signal passes through the transparent sample vessel prior to being received by the detector;
a plasma separator to separate plasma from a blood sample to create a plasma sample;
a dispenser adapted to pass a first portion of the blood sample into the transparent sample vessel at a first instance of time, the first portion being whole blood or lysed blood, and to pass the plasma sample into the transparent sample vessel at a second instance of time; and
a controller having a processor executing logic that when executed by the processor causes the processor to obtain first data generated by the detector indicative of the optical signal passing through the first portion of the blood sample, and second data generated by the detector indicative of the optical signal passing through the plasma sample, the logic causing the processor to calculate a total absorbance spectrum in which the first data is adjusted by the second data to remove effects of one or more unknown extracellular interferents in the blood sample.