	US 12,297,438 B2
	Gene expression elements and systems and use thereof
Kinneret Shefer, Shoham (IL)
Assigned to GENENEER LTD., Shoham (IL)
Appl. No. 17/419,759
Filed by GENENEER LTD., Shoham (IL)
PCT Filed Jan. 1, 2020, PCT No. PCT/IL2020/050004 § 371(c)(1), (2) Date Jun. 30, 2021, PCT Pub. No. WO2020/141528, PCT Pub. Date Jul. 9, 2020.
Claims priority of provisional application 62/787,302, filed on Jan. 1, 2019.
Prior Publication US 2022/0064656 A1, Mar. 3, 2022
Int. Cl. C12N 15/82 (2006.01)

CPC C12N 15/8209 (2013.01) [C12N 15/8216 (2013.01); C12N 15/8274 (2013.01); C12N 15/8282 (2013.01); C12N 15/8283 (2013.01); C12N 15/8286 (2013.01)]

19 Claims

1. An isolated expression control element (ECE), comprising a polyamine or polyamine analog responsive nucleic acid sequence having the nucleic acid sequence as set forth in SEQ ID NO: 3 flanked at its 5′ end and 3′ end by splice sites, further comprising at least one intron sequence flanking each of the splice sites, wherein the at least one intron length is from 10 nucleotides to 150 nucleotides.