US 12,297,300 B2
Hyaluronic acid-based zwitterionic polymer brush, preparation method thereof, and use thereof
Li Ren, Guangzhou (CN); Sa Liu, Guangzhou (CN); and Renjian Xie, Guangzhou (CN)
Assigned to South China University of Technology, Guangdong (CN)
Appl. No. 17/256,387
Filed by South China University of Technology, Guangzhou (CN)
PCT Filed Dec. 12, 2018, PCT No. PCT/CN2018/120505
§ 371(c)(1), (2) Date Dec. 28, 2020,
PCT Pub. No. WO2020/000916, PCT Pub. Date Jan. 2, 2020.
Claims priority of application No. 201810687134.3 (CN), filed on Jun. 28, 2018.
Prior Publication US 2021/0147583 A1, May 20, 2021
Int. Cl. C08B 37/08 (2006.01); A61K 31/728 (2006.01); A61L 27/20 (2006.01); A61L 31/04 (2006.01); A61P 19/02 (2006.01); C08F 130/02 (2006.01); C08G 81/02 (2006.01); C08L 5/08 (2006.01)
CPC C08B 37/0072 (2013.01) [A61K 31/728 (2013.01); A61L 31/042 (2013.01); A61P 19/02 (2018.01); C08F 130/02 (2013.01); C08G 81/025 (2013.01)] 5 Claims
 
1. A zwitterionic polymer brush based on hyaluronic acid and 2-methacryloyloxyethyl phosphorylcholine, comprising the following structure capable of binding to fibronectin and type II collagen in cartilage:

OG Complex Work Unit Chemistry
wherein n is an integer from 60-150, x is an integer from 589-686, and y is an integer from 125-230.