US 12,297,224 B2
Crystal form, preparation method, and application of 4'-substituted nucleoside
Junbiao Chang, Zhengzhou (CN); Jinfa Du, Zhengzhou (CN); Kaikai Zhu, Zhengzhou (CN); Kai Wang, Zhengzhou (CN); Jianyong Li, Zhengzhou (CN); and Chunxia Zhang, Zhengzhou (CN)
Assigned to HENAN GENUINE BIOTECH CO., LTD., Pingdingshan (CN)
Appl. No. 17/604,451
Filed by Henan Genuine Biotech Co., Ltd., Pingdingshan (CN)
PCT Filed Mar. 21, 2019, PCT No. PCT/CN2019/078992
§ 371(c)(1), (2) Date Oct. 18, 2021,
PCT Pub. No. WO2020/007070, PCT Pub. Date Jan. 9, 2020.
Claims priority of application No. 201810722856.8 (CN), filed on Jul. 2, 2018.
Prior Publication US 2023/0151048 A1, May 18, 2023
Int. Cl. C07H 19/16 (2006.01); A61K 31/505 (2006.01); A61K 31/5383 (2006.01); A61K 31/553 (2006.01); A61K 31/675 (2006.01); A61K 31/683 (2006.01); A61K 31/7068 (2006.01); A61K 31/7076 (2006.01); A61K 38/16 (2006.01); A61P 31/18 (2006.01); C07H 19/06 (2006.01)
CPC C07H 19/16 (2013.01) [A61K 31/505 (2013.01); A61K 31/5383 (2013.01); A61K 31/553 (2013.01); A61K 31/675 (2013.01); A61K 31/683 (2013.01); A61K 31/7068 (2013.01); A61K 31/7076 (2013.01); A61K 38/162 (2013.01); A61P 31/18 (2018.01); C07H 19/06 (2013.01); C07B 2200/13 (2013.01)] 2 Claims
 
1. A crystal form A of a compound of formula Ia:

OG Complex Work Unit Chemistry
wherein a CuKα X-ray powder diffraction (XRPD) spectrum of the crystal form A has diffraction peaks at diffraction angle 2θ positions of 6.13°±0.2°, 7.77°±0.2°, 9.43°±0.2°, 10.61°±0.2°, 11.88°±0.2°, 12.44°±0.2°, 12.80°±0.2°, 13.88°±0.2°, 14.28°±0.2°, 14.66°±0.2°, 15.51°±0.2°, 17.09°±0.2°, 17.55°±0.2°, 17.88°±0.2°, 18.95°±0.2°, 21.18°±0.2°, 21.86°±0.2°, 22.40°±0.2°, 22.87°±0.2°, 23.52°±0.2°, 24.93°±0.2°, 25.69°±0.2°, 26.63°±0.2°, 28.60°±0.2° and 30.46°±0.2°.