US 12,297,213 B2
Metal hydroxide complex comprising modified multilayer hydroxide structure comprising active ingredient and method of manufacturing same
Ho-Jun Kim, Seoul (KR); and Ki-Yeok Kim, Seoul (KR)
Assigned to CNPHARM CO., LTD., Seoul (KR); and HYUNDAI BIOSCIENCE CO., LTD., Gyeongsangbuk-do (KR)
Appl. No. 16/969,710
Filed by CNPHARM CO., LTD., Seoul (KR); and HYUNDAI BIOSCIENCE CO., LTD., Gyeongsangbuk-do (KR)
PCT Filed Sep. 23, 2019, PCT No. PCT/KR2019/012331
§ 371(c)(1), (2) Date Feb. 26, 2021,
PCT Pub. No. WO2020/075987, PCT Pub. Date Apr. 16, 2020.
Claims priority of application No. 10-2018-0120027 (KR), filed on Oct. 8, 2018.
Prior Publication US 2023/0192726 A1, Jun. 22, 2023
Int. Cl. C07F 3/06 (2006.01); A61K 8/02 (2006.01)
CPC C07F 3/06 (2013.01) 13 Claims
 
1. A metal hydroxide complex comprising:
a multilayer hydroxide structure of Chemical Formula I below, comprising a base layer, a surface layer and an active ingredient:
{[Mx(OH)z]B[My(OH)w]S}{(An)q}·m(H2O)  [Chemical Formula 1]
wherein [Mx(OH)z]B represents the base layer of the multilayer hydroxide structure, and [My(OH)w]S represents the surface layer of the multilayer hydroxide structure,
M is any one divalent metal cation selected from the group consisting of Zn2+,
x is 0.6 to 3,
y is more than 0 and up to 2,
z is 1 to 5,
w is more than 0 and up to 4,
z+w is 1 to 9,
q is 1 to 4,
mis 0.1 to 10,
n is a charge number of A, and
the active ingredient is represented by A, in which A is an anionic compound comprising ascorbic acid,
wherein the multilayer hydroxide structure has a powder-X-ray diffraction pattern having peak values of diffraction angles (2θ) of 5.96±1°, 33.46±1 and 59.3±1°.