US 12,296,094 B1
Devices and methods for treating lung diseases
Moshe Ashkenazi, Ganei-Tikva (IL); Gil Sokol, Ganey-Tikva (IL); Ori Efrati, Herzliya (IL); Itzik Mashiach, Tel-Aviv (IL); Diana Sverdlov, Tel-Aviv (IL); Ortal Shtayman, Tel-Aviv (IL); Imry Ben Avi, Tel-Aviv (IL); and Daniel Sorkin, Tel-Aviv (IL)
Assigned to Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat-Gan (IL); and Ramot at Tel-Aviv University Ltd., Tel-Aviv (IL)
Filed by Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat-Gan (IL); and Ramot at Tel-Aviv University Ltd., Tel-Aviv (IL)
Filed on Apr. 26, 2021, as Appl. No. 17/239,880.
Claims priority of provisional application 63/015,581, filed on Apr. 26, 2020.
Int. Cl. A61M 16/00 (2006.01); A61M 16/20 (2006.01)
CPC A61M 16/022 (2017.08) [A61M 16/202 (2014.02); A61M 16/0009 (2014.02)] 22 Claims
OG exemplary drawing
 
1. A method of using pressure to recruit lung regions of a patient, the method comprising administering, during each of one or more breath cycles:
during an inspiratory phase, providing a period of positive inspiration pressure extended to pressurize de-recruited lung regions via collateral airways;
during an expiratory phase, providing a reduction from the positive inspiration pressure down to a non-negative undershoot pressure, allowing pressure in pressurized de-recruited lung regions to mobilize mucous along main branch airways of the lung; and
providing an elevation of pressure from the undershoot pressure to a positive expiratory pressure, before lung volume reaches a breath cycle minimum; wherein:
within a first one or more administrations during said one or more breath cycles, the positive expiratory pressure is followed by initiation of a next inspiratory phase without suction; and
within a second one or more administrations during said one or more breath cycles following the first one or more administrations, the positive expiratory pressure is followed by a period of suction before the next inspiratory phase.