US 12,296,065 B2
Embolic compositions and methods
Jeffrey Groom, Belmont, MA (US); Craig Wiltsey, Waltham, MA (US); Quynh Pham, Methuen, MA (US); Nikhita Mansukhani, Allston, MA (US); Courtney Guertin, Watertown, MA (US); Lee Core, Needham, MA (US); and Upma Sharma, Somerville, MA (US)
Assigned to Arsenal Medical, Inc., Waltham, MA (US)
Filed by Arsenal Medical, Inc., Waltham, MA (US)
Filed on Jun. 27, 2024, as Appl. No. 18/756,702.
Application 18/756,702 is a continuation of application No. 18/502,937, filed on Nov. 6, 2023, granted, now 12,053,560.
Application 18/502,937 is a continuation of application No. 18/322,852, filed on May 24, 2023, granted, now 11,844,870, issued on Dec. 19, 2023.
Application 18/322,852 is a continuation of application No. 18/001,024, previously published as PCT/US2021/036636, filed on Jun. 9, 2021.
Claims priority of provisional application 63/036,564, filed on Jun. 9, 2020.
Prior Publication US 2024/0350700 A1, Oct. 24, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 24/06 (2006.01); A61K 47/02 (2006.01); A61K 47/34 (2017.01); A61K 49/04 (2006.01); A61L 24/00 (2006.01); A61L 24/02 (2006.01); A61L 24/04 (2006.01); C08L 83/04 (2006.01)
CPC A61L 24/06 (2013.01) [A61K 47/02 (2013.01); A61K 47/34 (2013.01); A61K 49/04 (2013.01); A61K 49/0409 (2013.01); A61L 24/0021 (2013.01); A61L 24/02 (2013.01); A61L 24/043 (2013.01); A61L 24/046 (2013.01); C08L 83/04 (2013.01); A61L 2400/06 (2013.01); A61L 2430/36 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A kit for forming crosslinkable compositions for vascular embolization, said kit comprising:
(a) a first suspension comprising a first crosslinkable polymer and a first imaging agent,
(b) a second suspension comprising a crosslinker and, optionally, a second imaging agent which is the same or different from the first imaging agent, wherein the first imaging agent and second imaging agent are bismuth trioxide,
(c) a dry composition comprising a first filler and optionally a second filler which is the same or different from the first filler, and
wherein the first suspension, second suspension, and dry composition, when mixed, form a crosslinkable composition having the first and second imaging agents at least in which a portion of the first and second imaging agents are dispersed in the crosslinkable composition.