| CPC A61L 24/02 (2013.01) [A61L 24/0036 (2013.01); A61L 24/0042 (2013.01); A61L 2400/04 (2013.01)] | 19 Claims |
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1. A method of producing a hemostatic composition, the method comprising:
mixing a clay material comprising a crystalline hydrated form of a layered silicate within a suspending liquid for a specified period of time so that platelets of the clay material are sufficiently dispersed in the suspending liquid to form a clear or substantially clear clay suspension;
spraying the clear or substantially clear clay suspension in order to form of droplets of the clear or substantially clear clay suspension having a diameter of less than or equal to about 250 micrometers, wherein the clear or substantially clear clay suspension is sprayed into an environment with a sufficiently low temperature to freeze the suspending liquid of the droplets to provide frozen droplets of the clear or substantially clear clay suspension; and
freeze-drying at least a portion of the frozen droplets to provide a powder comprising hollow or highly-porous microspheres comprising the clay material, wherein the hollow or highly-porous microspheres have a sphere-like or substantially sphere-like shape,
wherein the hollow or highly-porous microspheres have a diameter of from about 40micrometers to about 250 micrometers and comprise a porous structure with a plurality of pores formed in the microspheres, wherein each of the plurality of pores has a pore size of from about 1micrometer to about 10 micrometers, and
wherein the powder exhibits hemostatic properties.
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