US 12,296,054 B2
Method of preparing polymeric microparticles, polymeric microparticles, medical composition, cosmetic composition, medical articles and cosmetic articles using the same
Yunseop Kim, Daejeon (KR); Jung Youn Shin, Daejeon (KR); Chanjoong Kim, Daejeon (KR); Jee Seon Kim, Daejeon (KR); Kyung Oh Kim, Daejeon (KR); and Je Young Ryu, Daejeon (KR)
Assigned to LG CHEM, LTD., Seoul (KR)
Appl. No. 17/640,923
Filed by LG CHEM, LTD., Seoul (KR)
PCT Filed Jun. 1, 2021, PCT No. PCT/KR2021/006828
§ 371(c)(1), (2) Date Mar. 7, 2022,
PCT Pub. No. WO2021/246764, PCT Pub. Date Dec. 9, 2021.
Claims priority of application No. 10-2020-0066053 (KR), filed on Jun. 1, 2020; and application No. 10-2021-0070287 (KR), filed on May 31, 2021.
Prior Publication US 2022/0331260 A1, Oct. 20, 2022
Int. Cl. A61K 9/50 (2006.01); A61K 8/11 (2006.01); A61K 8/19 (2006.01); A61K 8/65 (2006.01); A61K 8/73 (2006.01); A61Q 19/00 (2006.01); C08J 3/12 (2006.01); C08J 3/24 (2006.01); C08L 5/08 (2006.01)
CPC A61K 9/5057 (2013.01) [A61K 8/11 (2013.01); A61K 8/19 (2013.01); A61K 8/65 (2013.01); A61K 8/735 (2013.01); A61K 9/5036 (2013.01); A61K 9/5089 (2013.01); A61Q 19/00 (2013.01); C08J 3/12 (2013.01); C08J 3/126 (2013.01); C08J 3/245 (2013.01); C08L 5/08 (2013.01); A61K 2800/10 (2013.01); A61K 2800/412 (2013.01); A61K 2800/651 (2013.01); A61K 2800/652 (2013.01); C08J 2305/08 (2013.01); C08J 2405/08 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of preparing polymeric microparticles comprising the steps of:
subjecting a mixture containing a biocompatible polymer and a metal ion to a crosslinking reaction to form crosslinked polymer particles; and
further crosslinking the crosslinked polymer particles in a polar solvent phase including an organic crosslinking agent containing at least one reactive functional group,
wherein the biocompatible polymer comprises a mixture of hyaluronic acid and gelatin.
 
9. Polymeric microparticles having a core-shell structure, comprising:
a core including a first biocompatible polymer, a metal ion, and an organic crosslinking agent containing at least one reactive functional group; and
a shell surrounding all or part of the core and including a second biocompatible polymer, a metal ion, and an organic crosslinking agent containing at least one reactive functional group, wherein the first biocompatible polymer comprises hyaluronic acid, and the second biocompatible polymer comprises gelatin.