US 12,296,052 B2
Oral compositions and the preparation methods thereof
Rosita Garcia, Change (FR); and Romain Charles, Meslay du Main (FR)
Assigned to CEVA SANTE ANIMALE, Libourne (FR)
Filed by CEVA SANTE ANIMALE, Libourne (FR)
Filed on Jan. 5, 2023, as Appl. No. 18/150,399.
Application 18/150,399 is a continuation of application No. 16/638,372, granted, now 11,559,491, previously published as PCT/EP2018/072297, filed on Aug. 17, 2018.
Claims priority of application No. 17306078 (EP), filed on Aug. 17, 2017.
Prior Publication US 2023/0146514 A1, May 11, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/20 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 31/365 (2006.01); A61K 31/4985 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/38 (2006.01); A61K 47/44 (2017.01)
CPC A61K 9/2095 (2013.01) [A61K 9/0056 (2013.01); A61K 9/1617 (2013.01); A61K 9/1682 (2013.01); A61K 31/365 (2013.01); A61K 31/4985 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/38 (2013.01); A61K 47/44 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A process for preparing a solid soft tablet composition comprising at least one active ingredient, at least one excipient, and a humectant at a concentration between 15.00% and 35.00% by weight, relative to the total weight of the solid soft tablet composition, wherein the process comprises the following steps:
i) mixing said at least one active ingredient, said at least one excipient, and said humectant in a granulator to obtain wet granules;
ii) spreading the wet granules and letting stand for 2 to 24 hours between 15 and 25° C.;
iii) compressing the granules obtained after step ii) with a tablet press; and
iv) collecting a solid soft tablet composition,
wherein the solid soft tablet composition is not sticky, is not friable and is hard enough to be manipulated and packaged.