US 12,296,049 B2
Immediate release dosage form
Jitendra Krishan Somani, Waterloo (CA); and Murali K. Vuppala, Collegeville, PA (US)
Assigned to Kenvue Brands LLC, Summit, NJ (US)
Filed by Kenvue Brands LLC, Summit, NJ (US)
Filed on Sep. 1, 2023, as Appl. No. 18/460,235.
Application 18/460,235 is a division of application No. 16/364,244, filed on Mar. 26, 2019, granted, now 11,779,541.
Prior Publication US 2023/0414520 A1, Dec. 28, 2023
Int. Cl. A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61K 31/192 (2006.01)
CPC A61K 9/2009 (2013.01) [A61K 9/2013 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 9/284 (2013.01); A61K 31/192 (2013.01)] 10 Claims
 
1. An immediate release solid dosage form comprising an intragranular portion and a carbonate portion, wherein the intragranular portion comprises 220 mg naproxen sodium, as well as compression filler, binder and disintegrant, wherein the carbonate portion comprises an effective amount of soluble carbonate at a particle size from about 50 microns to 200 microns so as to raise the pH and facilitate dissolution and absorption of the naproxen sodium to begin in a human's stomach in a fasted state, wherein the particle size of the intragranular portion is from about 200 microns to 400 microns, wherein the immediate release solid dosage form provides a blood plasma naproxen concentration of at least 15-20 μg/ml in 10 minutes or less, and wherein the solid dosage form does not include any other drug besides naproxen sodium.