US 12,296,046 B2
Micro-emulsion containing creatine fatty-ester, method for preparing said micro-emulsion and uses thereof
Aloïse Mabondzo, Paris (FR); Gabriela Ullio-Gamboa, Gif s/ Yvette (FR); Sophie Dezard, Forges les Bains (FR); Frédéric Taran, Gif s/ Yvette (FR); Anne-Cécile Guyot, Rueil-Mal-Maison (FR); Olivier Loreau, St Michel s/ Orge (FR); and Henri Benech, Paris (FR)
Assigned to COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, Paris (FR)
Appl. No. 17/051,215
Filed by COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, Paris (FR)
PCT Filed May 2, 2019, PCT No. PCT/EP2019/061293
§ 371(c)(1), (2) Date Oct. 28, 2020,
PCT Pub. No. WO2019/211399, PCT Pub. Date Nov. 7, 2019.
Claims priority of application No. 18305557 (EP), filed on May 3, 2018.
Prior Publication US 2021/0128467 A1, May 6, 2021
Int. Cl. A61K 31/202 (2006.01); A61K 9/107 (2006.01); A61K 31/221 (2006.01); A61K 9/00 (2006.01)
CPC A61K 9/1075 (2013.01) [A61K 31/202 (2013.01); A61K 31/221 (2013.01); A61K 9/0043 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A nasal composition in the form of a micro-emulsion for nasal administration, wherein said composition comprises (i) an oil phase comprising at least one omega 3 fatty acid or salt thereof and at least one glyceride, (ii) an aqueous phase and (iii) at least one non ionic surfactant(s), wherein said composition has a pH of from 4.5-6.5 and further comprises at least one creatine fatty ester or salt thereof.