	US 12,296,038 B2
	Topical composition containing ascorbic acid and/or salt thereof
Yu Kitaoka, Osaka (JP); Mariko Iwai, Osaka (JP); and Sho Yamashina, Osaka (JP)
Assigned to ROHTO PHARMACEUTICAL CO., LTD., Osaka (JP)
Appl. No. 17/279,296
Filed by ROHTO PHARMACEUTICAL CO., LTD., Osaka (JP)
PCT Filed Sep. 25, 2019, PCT No. PCT/JP2019/037537 § 371(c)(1), (2) Date Mar. 24, 2021, PCT Pub. No. WO2020/067132, PCT Pub. Date Apr. 2, 2020.
Claims priority of application No. 2018-179018 (JP), filed on Sep. 25, 2018.
Prior Publication US 2022/0031597 A1, Feb. 3, 2022
Int. Cl. A61K 8/67 (2006.01); A61K 8/34 (2006.01); A61Q 19/00 (2006.01)

CPC A61K 8/676 (2013.01) [A61K 8/345 (2013.01); A61K 8/678 (2013.01); A61Q 19/00 (2013.01); A61K 2800/10 (2013.01); A61K 2800/52 (2013.01); A61K 2800/5922 (2013.01)]

4 Claims

1. A topical composition comprising:

(A) from 1 to 10% by mass of at least one type selected from the group consisting of ascorbic acid and salts of ascorbic acid;

(B) at least 40% by mass of 1,3-propanediol;

(C) at least one type selected from the group consisting of tocopherol, salts of tocopherol, and derivatives of tocopherol; and

(D) water;

wherein the mass ratio of component (D) to component (A) is from 0.5 to 5.0 and the topical composition includes less than 20% by mass of glycol ether.