US 12,296,022 B2
D glutamate polyglutamated antifolates and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed on May 16, 2022, as Appl. No. 17/745,138.
Application 17/745,138 is a division of application No. 16/324,823, granted, now 11,344,628, previously published as PCT/US2017/046666, filed on Aug. 12, 2017.
Claims priority of provisional application 62/374,458, filed on Aug. 12, 2016.
Prior Publication US 2023/0115624 A1, Apr. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); A61K 9/127 (2025.01); A61K 9/1271 (2025.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); A61P 19/02 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 47/6913 (2017.08) [A61K 9/1271 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/545 (2017.08); A61K 47/64 (2017.08); A61K 47/645 (2017.08); A61K 47/6801 (2017.08); A61K 47/6849 (2017.08); A61K 47/6911 (2017.08); A61P 19/02 (2018.01); A61P 35/00 (2018.01); C07K 16/28 (2013.01); A61K 2300/00 (2013.01); B82Y 5/00 (2013.01); C07K 2317/73 (2013.01)] 27 Claims
 
1. A liposomal composition comprising a polyglutamated antifolate encapsulated by a pegylated liposome, wherein the polyglutamated antifolate comprises a D-glutamate and wherein the liposome does not contain a targeting moiety having specific affinity for a surface antigen on a target cell.