	US 12,296,021 B2
	Antibody conjugates and methods of making and using the same
Yun Cheol Kim, Walnut Creek, CA (US); Chao Bai Huang, San Leandro, CA (US); Penelope M. Drake, Castro Valley, CA (US); and David Rabuka, Kensington, CA (US)
Assigned to R.P. Scherer Technologies, LLC, Carson City, NV (US)
Filed by R.P. Scherer Technologies, LLC, Carson City, NV (US)
Filed on Aug. 15, 2022, as Appl. No. 17/888,336.
Application 17/888,336 is a division of application No. 16/491,124, granted, now 11,466,096, previously published as PCT/US2018/022178, filed on Mar. 13, 2018.
Claims priority of provisional application 62/473,161, filed on Mar. 17, 2017.
Prior Publication US 2023/0235079 A1, Jul. 27, 2023
Int. Cl. C07K 16/30 (2006.01); A61K 47/60 (2017.01); A61K 47/68 (2017.01); A61K 49/00 (2006.01)

CPC A61K 47/6849 (2017.08) [A61K 47/60 (2017.08); A61K 47/6851 (2017.08); A61K 49/0002 (2013.01); C07K 16/30 (2013.01); C07K 2317/52 (2013.01)]

13 Claims

1. An antibody comprising an immunoglobulin (Ig) heavy chain polypeptide and an Ig light chain polypeptide, wherein:

excluding a sulfatase motif having the amino acid sequence of LCTPSR (SEQ ID NO: 561, the Ig heavy chain polypeptide has 97% or more sequence identity to the amino acid sequence set forth in SEQ ID NO: 656, and wherein

the Ig heavy chain polypeptide comprises an insertion of the sulfatase motif (LCTPSR (SEQ ID NO: 561)) before the glutamine residue at the 58^thposition of the amino acid sequence set forth in SEQ ID NO: 1 thereby producing in the Ig heavy chain polypeptide the amino acid sequence of AVLLCTPSRQSS (SEQ ID NO: 657).