| CPC A61K 47/68031 (2023.08) [A61K 47/6849 (2017.08); A61K 47/6889 (2017.08)] | 8 Claims |
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1. A compound comprising Fc binding unit having a structure of formula 2-2:
 wherein,
Da is a spacer A, wherein the spacer A is unsubstituted C3 alkylene,
La is linker A, wherein the linker A is a bond, unsubstituted C1-30 alkylene, or unsubstituted C1-30 heteroalkylene, wherein the heteroalkylene comprises one or more heteroatoms, and wherein each of heteroatoms is independently selected from N, O, and S,
X is —CH2— or —O—,
Ra1 is methyl,
both of Ra2 and Ra3 are H,
Ja is —C(═O)—,
RG is a reactive group, wherein the reactive group has one of the following structures:
 wherein,
hn is integer of 1 to 3, and
each of RH is independently selected from —R, ═O, ═S, —NO2, —CR3, —NR2, ═NR, —OR, —SR, —C(═O)R, —C(═O)CR3, —C(═O) OR, and —C(═O)NR2, wherein each of R is independently selected from H, halogen, C1-6alkyl, C3-10 cycloalkyl, C3-10 heterocycloalkyl, aryl, heteroaryl, —OH, —NH2, —COOH, ═O, ═S, and —SH, and
FcBU is a Fc binding unit, wherein the Fc binding unit consists of a Fc binding peptide or a modified Fc binding peptide, wherein the Fc binding peptide has the following structure:
 wherein Xa1′ is
 wherein,
m is 3,
Jf is —NH—,
each of * and ** indicates an attachment point of Xa1′ with the amino acid residue adjacent to Xa1′, and
*** indicates an attachment point with Ja, and
wherein two cysteine residues of the Fc binding peptide are optionally covalently linked to each other, and
wherein the modified Fc binding peptide is a peptide which is modified by modifying the Fc binding peptide by at least one of followings:
a) amidation of C terminal of the Fc binding peptide, and
b) conjugation of a polyethylene glycol moiety (PEG moiety) to N terminal of the Fc binding peptide.
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