US 12,295,971 B2
Compositions and methods for enhancing adoptive T cell therapeutics
Kole Roybal, San Francisco, CA (US); Julie Garcia, San Francisco, CA (US); Iowis Zhu, San Francisco, CA (US); Jaehyuk Choi, Chicago, IL (US); and Jay Daniels, Chicago, IL (US)
Assigned to The Regents of the University of California, Oakland, CA (US); and Northwestern University, Evanston, IL (US)
Filed by The Regents of the University of California, Oakland, CA (US); and Northwestern University, Evanston, IL (US)
Filed on Apr. 9, 2024, as Appl. No. 18/630,828.
Application 18/630,828 is a continuation of application No. PCT/US2023/075738, filed on Oct. 2, 2023.
Claims priority of provisional application 63/412,300, filed on Sep. 30, 2022.
Prior Publication US 2024/0270802 A1, Aug. 15, 2024
Int. Cl. A61K 35/17 (2025.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 9/16 (2006.01); C12N 9/22 (2006.01); C12N 15/63 (2006.01)
CPC A61K 35/17 (2013.01) [A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/4211 (2025.01); A61K 40/424 (2025.01); A61K 40/4251 (2025.01); A61P 35/00 (2018.01); C07K 14/4702 (2013.01); C07K 14/4747 (2013.01); C07K 14/82 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C12N 9/16 (2013.01); C12N 9/22 (2013.01); C12N 15/63 (2013.01); A61K 2239/13 (2023.05); C12N 2310/20 (2017.05); C12N 2510/00 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A nucleic acid construct comprising a nucleic acid sequence encoding a polypeptide, the polypeptide comprising:
a. a caspase-associated recruitment domain (CARD) containing protein; and
b. a Src Homology region 2 (SH2) domain,
wherein the polypeptide comprises or consists of a sequence having at least 85% identity to SEQ ID NO: 206.