CPC A61K 31/737 (2013.01) [A61K 9/19 (2013.01); A61K 31/385 (2013.01); A61K 31/423 (2013.01); A61K 31/427 (2013.01); A61K 31/428 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01)] | 14 Claims |
1. A composition comprising sulfobutyl ether-beta-cyclodextrin and a compound of formula (I);
![]() or a pharmaceutically acceptable tautomer, salt or solvate thereof wherein:
X is S, O or NHOH;
Y is CH, C or N;
R1, R2, R4 and R5 each independently is hydrogen, hydroxy, halo, amino, alkylsulfonyl, aminosulfonyl, cyano, nitro, carboxy, aryl, alkoxy, haloalkyl, alkylamino, aminoalkyl, nitrooxyalkyl or carboxyalkyl;
R3 is hydroxy or methoxy; or R3 and R2 together with the carbon atoms to which they are attached form a 5-membered heteroaryl moiety wherein —R3—R2— is -A—CR6═B— or —B═CR6-A-; wherein:
A is O, S or NR7; wherein R7 is hydrogen, C1-C8 alkyl or alkyloxycarbonyl;
B is CH or N; and
R6 is hydrogen, hydroxy, halo, amino, alkylsulfonyl, aminosulfonyl, cyano, nitro, carboxy, aryl, alkoxy, haloalkyl, alkylamino, aminoalkyl, nitrooxyalkyl or carboxyalkyl;
wherein the molar ratio of the sulfobutyl ether-beta-cyclodextrin to the compound of formula (I) ranges from 10 to 400.
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