US 12,295,959 B2
Phenoxy and benzyloxy substituted psychoplastogens and uses thereof
Noel Aaron Powell, Westford, MA (US); Milan Chytil, Acton, MA (US); and Florence F. Wagner, Ashland, MA (US)
Assigned to DELIX THERAPEUTICS, INC., Bedford, MA (US)
Filed by Delix Therapeutics, Inc., Bedford, MA (US)
Filed on Jun. 13, 2024, as Appl. No. 18/742,438.
Application 18/742,438 is a continuation of application No. PCT/US2022/052870, filed on Dec. 14, 2022.
Claims priority of provisional application 63/387,222, filed on Dec. 13, 2022.
Claims priority of provisional application 63/290,036, filed on Dec. 15, 2021.
Prior Publication US 2024/0335454 A1, Oct. 10, 2024
Int. Cl. A61K 31/55 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); C07D 487/04 (2006.01)
CPC A61K 31/55 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/08 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/4825 (2013.01); A61K 9/4866 (2013.01); A61P 25/24 (2018.01); A61P 25/28 (2018.01); C07D 487/04 (2013.01)] 30 Claims
 
1. A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:

OG Complex Work Unit Chemistry
wherein:
R1 is ORa, wherein Ra is an optionally substituted arylalkyl;
R2 is hydrogen;
R3 is hydrogen;
R4 is hydrogen;
R5 is an unsubstituted or substituted alkyl, or hydrogen; and
R6 is an unsubstituted or substituted alkyl, or hydrogen.