| CPC A61K 31/47 (2013.01) [C07D 215/06 (2013.01)] | 6 Claims |
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1. A compound represented by the following formula (I):
 or a pharmaceutically acceptable salt thereof,
wherein:
X is N or N-oxide;
n is 0 or 1;
R1 is selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) hydroxyl, (4) —NH2, (5) —NH—C1-6 alkyl and (6) —S(O)m—C1-6 alkyl;
wherein m is independently 0, 1 or 2;
R2 is selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) C1-6 alkyl and (4) —O—C1-6 alkyl; wherein the C1-6 alkyl or the —O—C1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of: halogen, hydroxyl, —O—C1-6 alkyl, —CN, —NR9aR10a, —(C═O)—R9a, —(C═O)—NR9aR10a and —S(O)m—R9a; wherein m is independently 0, 1 or 2;
R1 may form ═CH2 or ═O with R2;
R3 is independently selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) C1-6 alkyl and (4) —O—C1-6 alkyl;
p is 0, 1, 2 or 3;
when p is 2 or 3, each R3 is the same or different;
R4 is selected from the group consisting of:
(1) hydrogen, (2) halogen and (3) hydroxyl;
R5 is hydrogen or C1-6 alkyl;
R6 is selected from the group consisting of:
(1) hydrogen, (2) C1-6 alkyl, (3) hydroxyC1-6 alkyl, (4) C1-6 alkoxy C1-6 alkyl and (5) heterocyclyl C1-6 alkyl;
R5 may form a saturated 3 to 7 membered ring with R6 which may contain a nitrogen atom, an oxygen atom, a sulfur atom or a double bond; or a saturated or unsaturated bicyclic 9 to 10 membered ring with R6 which may contain a nitrogen atom, an oxygen atom or a sulfur atom;
wherein the saturated 3 to 7 membered ring or the saturated or unsaturated bicyclic 9 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydroxyl, (2) halogen, (3) —O-aryl and (4) —O—C1-6 alkylaryl;
R7a and R7b are independently selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) hydroxyl, (4) C1-6 alkyl and (5) —NR9bR10b;
R7a may form a 3 to 7 membered ring with R5 which may contain a nitrogen atom or an oxygen atom; or
R7a may form a 3 to 7 membered ring with R7b which may contain a nitrogen atom or an oxygen atom;
q is 0 or 1;
R8 is
C3-10 cycloalkyl, wherein the C3-10 cycloalkyl is unsubstituted or substituted with one or more halogen or hydroxyl; or (7) heterocyclyl, (8) aryl, or (11) heteroaryl, wherein the heterocyclyl, aryl, or heteroaryl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of: halogen, hydroxyl, —O—C1-6 alkyl, —O—C1-6 haloalkyl, —C3-7 cycloalkyl, —O—C3-7 cycloalkyl, hydroxyl-C1-6 alkoxy, —CN, —NR9bR10b, —(C═O)—R9b, —(C═O)—NR9bR10b, —NR9b—(C═O)—R10b, —NR11—(C═O)—NR9bR10b, —NR9b—(C═O)—OR10b, —NR9b—S(O)m—R10b, —NR11—S(O)m—NR9bR10b, —S(O)m—R9b and C1-6 alkyl which may be substituted one or more with halogen, hydroxyl, —O—C1-6 alkyl or NR9bR10b, wherein m is independently 0, 1 or 2;
R9a, R9b, R10a, R10b or R11 is independently selected from the group consisting of:
(1) hydrogen, (2) hydroxyl, (3) C1-6 alkyl and (4) hydroxyC1-6 alkyl;
R9a may form a 4 to 7 membered ring with R10a which may contain one or more independently selected from the group consisting of: nitrogen atom, oxygen atom, sulfur atom and double bond, wherein the 4 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydroxyl, (2) halogen, (3) C1-6 alkyl and (4) —O—C1-6 alkyl;
R9b may form a 4 to 7 membered ring with R10b which may contain one or more independently selected from the group consisting of: nitrogen atom, oxygen atom, sulfur atom and double bond, wherein the 4 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: (1) hydroxyl, (2) halogen and (3) C1-6 alkyl.
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