	US 12,295,933 B2
	Methods and compositions to treat and diagnose diseases or pathologies associated with inflammation of the sinuses and nasal cavity
Benjamin S. Bleier, Weston, MA (US)
Assigned to Massachusetts Eye and Ear Infirmary, Boston, MA (US)
Appl. No. 17/442,730
Filed by Massachusetts Eye and Ear Infirmary, Boston, MA (US)
PCT Filed Mar. 24, 2020, PCT No. PCT/US2020/024476 § 371(c)(1), (2) Date Sep. 24, 2021, PCT Pub. No. WO2020/198232, PCT Pub. Date Oct. 1, 2020.
Claims priority of provisional application 62/823,233, filed on Mar. 25, 2019.
Prior Publication US 2022/0168260 A1, Jun. 2, 2022
Int. Cl. A61K 31/277 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61P 11/02 (2006.01)

CPC A61K 31/277 (2013.01) [A61K 9/0043 (2013.01); A61K 45/06 (2013.01); A61P 11/02 (2018.01)]

20 Claims

1. A method of treating rhinosinusitis in a subject, having elevated body mass index and/or elevated mucus total P-gp levels, the method comprising:

identifying that the subject has chronic rhinosinusitis; and

administering a composition comprising 5-150 mg verapamil to nasal passages and sinuses of the subject using a high volume, low pressure irrigation with normal saline, wherein the verapamil is administered locally to the subject's nasal passage and sinuses by irrigation with a high volume of saline.