US 12,295,916 B2
Process for making aqueous therapeutic particle having stable exterior water clustering with nanosized thickness
Karl P. Dresdner, Jr., Haddonfield, NJ (US); Michael Raymond Cary, Lexington, SC (US); Chase Hudson, Provo, UT (US); and Nathan A. Beckham, Provo, UT (US)
Filed by Karl P. Dresdner, Jr., Haddonfield, NJ (US); Michael Raymond Cary, Lexington, SC (US); Chase Hudson, Provo, UT (US); and Nathan A. Beckham, Provo, UT (US)
Filed on Apr. 30, 2020, as Appl. No. 16/873,552.
Claims priority of provisional application 62/921,280, filed on Jun. 8, 2019.
Claims priority of provisional application 62/920,747, filed on May 13, 2019.
Claims priority of provisional application 62/920,450, filed on Apr. 30, 2019.
Prior Publication US 2020/0345585 A1, Nov. 5, 2020
Int. Cl. A61K 9/00 (2006.01); A23L 2/52 (2006.01); A61J 3/07 (2006.01); A61K 9/51 (2006.01); A61K 31/05 (2006.01); C02F 9/00 (2023.01); C02F 1/00 (2023.01); C02F 1/32 (2023.01); C02F 1/44 (2023.01); C02F 1/469 (2023.01); C02F 103/04 (2006.01)
CPC A61J 3/07 (2013.01) [A23L 2/52 (2013.01); A61K 9/0095 (2013.01); A61K 9/5115 (2013.01); A61K 9/5192 (2013.01); A61K 31/05 (2013.01); C02F 9/00 (2013.01); A23V 2002/00 (2013.01); C02F 1/001 (2013.01); C02F 1/32 (2013.01); C02F 1/441 (2013.01); C02F 1/4691 (2013.01); C02F 2103/04 (2013.01)] 14 Claims
 
1. A process for making a composition comprising nanosized water clusters encapsulating therapeutic particles of a non-H2O substance in a purified water, the process comprising the steps of:
mixing an ingredient comprising the therapeutic particles of the non-H2O substance with the purified water to make a mixture comprising water clusters encapsulating the therapeutic particles of the non-H2O substance in the purified water;
flowing a process stream comprising the mixture through a transfer pipe and a nozzle having a single jet opening into and through a hollow cylinder cavity in a hollow cylinder to make the composition comprising the nanosized water clusters encapsulating the therapeutic particles of the non-H2O substance in the purified water in the process stream,
wherein the nozzle having the single jet opening is situated at a proximal end inside the hollow cylinder cavity and comprises:
(i) a nozzle proximal side with one nozzle input opening connected to the transfer pipe;
(ii) the single jet opening with one jet bore hole through the nozzle connected to the one nozzle input opening; and
(iii) a nozzle distal side where the one jet bore hole is directed to expel the process stream from outer surface of the nozzle at an angle into the hollow cylinder cavity towards an inner surface of the hollow cylinder, and
wherein the process stream contacts the inner surface of the hollow cylinder wall and has a spiral flow pattern through the hollow cylinder cavity directed towards distal end of the hollow cylinder; and
removing the composition comprising the nanosized water clusters encapsulating the therapeutic particles of the non-H2O substance in the purified water from the hollow cylinder cavity,
wherein the composition comprising the nanosized water clusters encapsulating the therapeutic particles of the non-H2O substance in the purified water has an increased bioavailability compared to the bioavailability of the mixture comprising the water clusters encapsulating the therapeutic particles of the non-H2O substance in the purified water.