US 12,295,881 B2
Topical ocular delivery devices and methods for using the same
Yehuda Ivri, Newport Coast, CA (US)
Assigned to Bausch + Lomb Ireland Limited, Dublin (IE)
Appl. No. 16/972,085
Filed by Bausch + Lomb Ireland Limited, Dublin (IE)
PCT Filed Jul. 2, 2019, PCT No. PCT/US2019/040354
§ 371(c)(1), (2) Date Dec. 4, 2020,
PCT Pub. No. WO2020/010116, PCT Pub. Date Jan. 9, 2020.
Claims priority of provisional application 62/693,818, filed on Jul. 3, 2018.
Prior Publication US 2021/0220169 A1, Jul. 22, 2021
Int. Cl. A61F 9/00 (2006.01)
CPC A61F 9/0008 (2013.01) 16 Claims
OG exemplary drawing
 
1. A fluid delivery device, the device comprising:
(a) a fluid package comprising:
(i) a reservoir comprising an ophthalmic formulation; and
(ii) an aperture through which the ophthalmic formulation can be directed, the aperture having a diameter ranging from 200 to 350 μm;
(b) a pin member being in axial alignment with the aperture and engaging the reservoir; and
(c) an electromagnetic actuator configured to axially oscillate the pin member while imparting pressure fluctuations to the fluid to eject fluid from the reservoir through the aperture at a velocity in a range from 10 to 500 cm/sec, which results in minimal discomfort during topical ocular delivery;
wherein the electromagnetic actuator comprises an electromagnet and a permanent magnet in operational proximity to each other; and
wherein the permanent magnet is positioned at a first region of a cantilever beam and the electromagnetic actuator further comprises an anchor positioned at a second region of the cantilever beam and configured to transmit oscillatory displacement force to an external surface of the fluid package.