US 12,295,836 B2
Prosthetic heart valve comprising a stent structure having a conical-convex inflow region and a linear cylindrical outflow region
Karsten Koop, Rostock (DE); André Hein, Rostock (DE); Paul Goebel, Rostock (DE); Imanol Flores, Rostock (DE); Andreas Hof, Luebeck (DE); Ulrich Sitz, Rostock (DE); Maik Neitzel, Wissmar (DE); Thomas Kuske, Rostock (DE); Max Linde, Rostock (DE); Stephan Rothstock, Berlin (DE); Matteo Astorino, Buelach (CH); and Giuseppe Pisani, Buelach (CH)
Assigned to BIOTRONIK AG, Buelach (CH)
Appl. No. 17/414,250
Filed by BIOTRONIK AG, Buelach (CH)
PCT Filed Dec. 19, 2019, PCT No. PCT/EP2019/086141
§ 371(c)(1), (2) Date Jun. 15, 2021,
PCT Pub. No. WO2020/127616, PCT Pub. Date Jun. 25, 2020.
Claims priority of application No. 102018133133.9 (DE), filed on Dec. 20, 2018; and application No. 19179715 (EP), filed on Jun. 12, 2019.
Prior Publication US 2022/0054260 A1, Feb. 24, 2022
Int. Cl. A61F 2/24 (2006.01); A61F 2/915 (2013.01)
CPC A61F 2/2418 (2013.01) [A61F 2002/91525 (2013.01); A61F 2250/0026 (2013.01); A61F 2250/0039 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A prosthetic heart valve, comprising:
a stent structure that is configured to expand from a compressed state for transluminal delivery to a natural expanded state, the stent structure comprising a mesh structure that has an essentially tubular shape and that furthermore defines a circumference with contours, wherein the contours define a proximal inlet region, a distal outlet region, and an intermediate transition region, wherein the intermediate transition region connects the inlet region and outlet region to each another, and wherein the mesh structure comprises a plurality of closed cells that in the longitudinal direction of the prosthetic heart valve have varying cell sizes and cell configurations to define a plurality of cell patterns that vary in size between the proximal inlet region, the distal outlet region, and the intermediate transition region, and
a valve arrangement that is arranged inside a lumen of the stent structure, wherein:
the cells in the inlet region are formed and arranged to define a conical-convex outer shape across the entire circumference of the inlet region,
the cells in the outlet region are shaped and arranged to define a linear cylindrical outer shape across the entire circumference of the outlet region,
two or more cells in the transition region are shaped and arranged for permitting a cell surface area of suitable size for free access to the coronary arteries, and
the inlet region comprises a higher number of smaller cells than the outlet region to create, when the stent structure is in the expanded state, a higher maximum radial force in the inlet region in direct comparison to a lower maximum radial force in the outlet region and in the transition region, wherein the transition region has the smallest diameter of the entire stent structure.