US 12,295,730 B2
Method of determining a concentration of an analyte in a bodily fluid and mobile device configured for determining a concentration of an analyte in a bodily fluid
Max Berg, Mannheim (DE); Fredrik Hailer, Limburgerhof (DE); Bernd Limburg, Soergenloch (DE); Daria Skuridina, Berlin (DE); Volker Tuerck, Berlin (DE); and Momme Winkelnkemper, Berlin (DE)
Assigned to Roche Diabetes Care, Inc., Indianapolis, IN (US)
Filed by Roche Diabetes Care, Inc., Indianapolis, IN (US)
Filed on Dec. 16, 2021, as Appl. No. 17/553,382.
Application 17/553,382 is a continuation of application No. PCT/EP2020/067444, filed on Jun. 23, 2020.
Claims priority of application No. 19 182 555 (EP), filed on Jun. 26, 2019.
Prior Publication US 2022/0104736 A1, Apr. 7, 2022
Int. Cl. A61B 5/145 (2006.01); A61B 5/15 (2006.01); G01N 21/78 (2006.01); G01N 21/84 (2006.01); G06T 5/92 (2024.01); G06T 7/00 (2017.01); G06T 7/80 (2017.01)
CPC A61B 5/14546 (2013.01) [A61B 5/150358 (2013.01); G01N 21/78 (2013.01); G01N 21/8483 (2013.01); G06T 5/92 (2024.01); G06T 7/0012 (2013.01); G06T 7/80 (2017.01); G01N 2021/8488 (2013.01); G01N 2201/0221 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of determining concentration of an analyte in a body fluid using a mobile device having a camera, the method comprising:
a) using the camera to take a series of calibration images of a region of interest of an object, wherein the calibration images differ in their brightness, and wherein the mobile device automatically applies to the calibration images a tone mapping function that renders the images taken by the camera less suitable for analytical measurements;
b) deriving from each calibration image a key calibration figure characteristic for the tone mapping function;
c) using the key calibration figures derived in step b) to approximate the tone mapping function;
d) taking an analysis image of at least part of a test field of an optical test strip, the test field having the body fluid applied thereto; and
e) determining the concentration of the analyte in the body fluid from the analysis image of the test field while taking into account the approximated tone mapping function, whereby the accuracy of the determined analyte concentration is improved by correcting for the effect of the tone mapping function.