US 12,295,637 B2
Method and apparatus for controlled delivery of pulsed electric field ablative energy to tissue
Raju Viswanathan, Mountain View, CA (US)
Assigned to Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed by Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed on Aug. 7, 2020, as Appl. No. 16/988,305.
Application 16/988,305 is a continuation of application No. PCT/US2019/017322, filed on Feb. 8, 2019.
Claims priority of provisional application 62/628,163, filed on Feb. 8, 2018.
Prior Publication US 2021/0022794 A1, Jan. 28, 2021
Int. Cl. A61B 18/12 (2006.01); A61B 18/14 (2006.01); A61B 17/00 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/1206 (2013.01) [A61B 18/1492 (2013.01); A61B 2017/00172 (2013.01); A61B 2018/0016 (2013.01); A61B 2018/00267 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00654 (2013.01); A61B 2018/00708 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00988 (2013.01); A61B 2018/124 (2013.01); A61B 2018/126 (2013.01); A61B 2018/1407 (2013.01); A61B 2018/1467 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A generator, comprising:
a set of electrode channels coupled to a set of electrodes during use, wherein each electrode channel from the set of electrode channels includes an output channel, wherein each output channel is configured to be coupled to an electrode during use, each electrode channel from the set of electrode channels including a first switch from a first set of switches and a second switch from a second set of switches, the first switch and the second switch connected in series in each electrode channel with the output channel therebetween;
a set of energy sources coupled to a third set of switches, the third set of switches configured to switch from an OFF state to an ON state to couple the set of energy sources to the set of electrodes;
a set of resistors coupled to the second set of switches, the second set of switches configured to switch from an OFF state to an ON state to couple the set of resistors to the set of electrodes;
a sensing circuit configured to measure an output current of the set of electrode channels; and
a processor coupled to the first set of switches, the second set of switches, the third set of switches, and the sensing circuit, the processor configured to:
set a subset of the third set of switches to the ON state to couple a subset of the energy sources to the electrode channels;
set a subset of the first set of switches to the ON state and a subset of the second set of switches to the ON state to configure a first subset of the electrode channels as anodes and a second subset of the electrode channels as cathodes; and
deliver a first pulse waveform to the first subset and the second subset of electrode channels using the subset of energy sources, such that the output current is measured by the sensing circuit;
adjust at least one of a voltage delivered by the set of energy sources or a resistance value of the set of resistors based on the output voltage measured by the sensing circuit, such that a second pulse waveform delivered after the adjusting has an amplitude different than the first pulse waveform.