US 12,295,580 B2
Systems, devices, and methods for adjusting blood flow in a body lumen
Yael Shohat, Herzliya (IL); Ofer Razi, Tel Aviv (IL); Lihu Avitov, Tel Aviv (IL); and Raphael Benary, Tel Aviv (IL)
Assigned to REVAMP MEDICAL LTD., Netania (IL)
Appl. No. 17/413,391
Filed by Revamp Medical Ltd., Netania (IL)
PCT Filed Dec. 11, 2019, PCT No. PCT/IL2019/051360
§ 371(c)(1), (2) Date Jun. 11, 2021,
PCT Pub. No. WO2020/121309, PCT Pub. Date Jun. 18, 2020.
Claims priority of provisional application 62/777,788, filed on Dec. 11, 2018.
Prior Publication US 2022/0061852 A1, Mar. 3, 2022
Int. Cl. A61B 17/12 (2006.01); A61M 25/00 (2006.01); A61B 17/00 (2006.01)
CPC A61B 17/12036 (2013.01) [A61B 17/1204 (2013.01); A61B 17/12109 (2013.01); A61B 17/12168 (2013.01); A61M 25/0082 (2013.01); A61B 2017/0042 (2013.01); A61B 2017/1205 (2013.01); A61M 2025/0002 (2013.01); A61M 2025/0004 (2013.01); A61M 25/0074 (2013.01); A61M 2210/1082 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A renal function alteration system comprising:
a blood-flow regulation device comprising:
an inner tube,
an expandable, adjustable member (EAM) coupled to the inner tube, the EAM comprising:
a proximal end and a distal end;
a cylindrical section positioned between the proximal and distal end of the EAM;
a plurality of radially inwardly foldable leaflets connected between a distal end of the cylindrical section and an adjustable opening at the distal end of the EAM; and
a blood impervious cover configured to cover at least a portion of a distal end of the cylindrical section and an outer surface of the foldable leaflets such that blood flows through the cylindrical section and out the adjustable opening;
wherein the inner tube passes through the cylindrical section of the adjustable opening;
a downstream tip member coupled to a distal portion of the inner tube which is distal to the EAM, the downstream tip member being coupled to a first fluid pressure sensor, and
a second fluid pressure sensor coupled to the blood flow regulation device proximal to the EAM;
a proximal control handle including a controller operatively coupled to the foldable leaflets and configured to control the size of the adjustable opening;
a fluid connector coupled to the proximal control handle;
and
a supply of a therapeutic agent in fluid communication with the fluid connector,
wherein upon delivering the EAM to a site near a kidney, the adjustable opening of the EAM is adjusted to effect a desired reduction in blood-flow at the site, and an amount of the supply of therapeutic agent is delivered to the site via the fluid connector.