US 12,293,821 B2
Computational pathology approach for retrospective analysis of tissue-based companion diagnostic driven clinical trial studies
Michael Barnes, Tucson, AZ (US); Christophe Chefd'hotel, Tucson, AZ (US); and Srinivas Chukka, Tucson, AZ (US)
Assigned to VENTANA MEDICAL SYSTEMS, INC., Tucson, AZ (US)
Filed by Ventana Medical Systems, Inc., Tuscon, AZ (US)
Filed on Mar. 21, 2024, as Appl. No. 18/612,913.
Application 18/612,913 is a continuation of application No. 18/336,890, filed on Jun. 16, 2023, granted, now 11,972,859.
Application 18/336,890 is a continuation of application No. 16/907,632, filed on Jun. 22, 2020, granted, now 11,721,427, issued on Aug. 8, 2023.
Application 16/907,632 is a continuation of application No. PCT/EP2018/085308, filed on Dec. 17, 2018.
Claims priority of provisional application 62/610,216, filed on Dec. 24, 2017.
Prior Publication US 2024/0257950 A1, Aug. 1, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G06K 9/00 (2022.01); G06T 7/00 (2017.01); G06V 20/69 (2022.01); G16H 30/40 (2018.01); G16H 50/20 (2018.01); G16H 50/70 (2018.01)
CPC G16H 30/40 (2018.01) [G06T 7/0012 (2013.01); G06V 20/695 (2022.01); G06V 20/698 (2022.01); G16H 50/20 (2018.01); G16H 50/70 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A method comprising:
calculating a first correlation matrix based on first tissue feature data for a first patient population, the first tissue feature data generated based on a first feature metric calculated from a plurality of first images of a plurality of first biological samples derived from the first patient population;
calculating a second correlation matrix based on second tissue feature data for a second patient population, the second tissue feature data generated based on a second feature metric calculated from a plurality of second images of a plurality of second biological samples derived from the second patient population; and
determining, based on a comparison of the first correlation matrix and second correlation matrix, that the first tissue feature data is similar to the second tissue feature data.