US 12,293,513 B2
Systems and methods for generating patient-specific corneal cross-linking treatment patterns
David Usher, Waltham, MA (US); Mikhail Smirnov, North Andover, MA (US); Behrouz Tavakol, Lexington, MA (US); and Grace Lytle, Bedford, MA (US)
Assigned to AVEDRO, INC., Burlington, MA (US)
Filed by AVEDRO, INC., Waltham, MA (US)
Filed on Mar. 8, 2022, as Appl. No. 17/689,515.
Claims priority of provisional application 63/158,023, filed on Mar. 8, 2021.
Prior Publication US 2022/0284575 A1, Sep. 8, 2022
Int. Cl. G06T 7/00 (2017.01); A61B 3/10 (2006.01); A61P 27/02 (2006.01)
CPC G06T 7/0012 (2013.01) [A61B 3/102 (2013.01); A61P 27/02 (2018.01); G06T 2207/10101 (2013.01); G06T 2207/30041 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for treating a cornea having a cone center, comprising:
receiving tomographic data for a cornea;
identifying a keratoconic defect in the cornea based on the tomographic data; and,
segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect,
wherein segmenting the keratoconic defect into treatment zones includes creating elliptical boundaries for the treatment zones based on segmentation data, wherein the elliptical boundaries are created by evaluating a predefined number of meridians built from the cone center, and
wherein segmenting the keratoconic defect into treatment zones includes post-processing the boundaries for the treatment zones to at least one of: reduce eccentricity of treatment shapes for the treatment zones, scale up or down treatment shapes for the treatment zones, or modify treatment zone areas.