US 12,293,306 B2
Method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a specialized prediction model
Eduardo Abeliuk, Palo Alto, CA (US); Juan Andrés Ramírez Neilson, Santiago (CL); Andrés Igor Pérez Manríquez, Santiago (CL); and Diego Francisco Valenzuela Iturra, Santiago (CL)
Assigned to TESELAGEN BIOTECHNOLOGY INC., San Francisco, CA (US)
Filed by TeselaGen Biotechnology Inc., San Francisco, CA (US)
Filed on Apr. 3, 2023, as Appl. No. 18/295,158.
Application 18/295,158 is a continuation of application No. 16/725,642, filed on Dec. 23, 2019, granted, now 11,620,544.
Claims priority of provisional application 62/784,101, filed on Dec. 21, 2018.
Prior Publication US 2024/0054365 A1, Feb. 15, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G06F 17/00 (2019.01); G06N 5/04 (2023.01); G06N 20/00 (2019.01); G16B 20/00 (2019.01); G16B 40/00 (2019.01)
CPC G06N 5/04 (2013.01) [G06N 20/00 (2019.01); G16B 20/00 (2019.02); G16B 40/00 (2019.02)] 21 Claims
OG exemplary drawing
 
1. A method executed by one or more computing devices for efficiently optimizing a phenotype with a specialized prediction model, the method comprising:
training, by at least one of the one or more computing devices, a phenotype prediction model based at least in part on a plurality of experimental data points and one or more constraints, the plurality of experimental data points comprising the genotype information and corresponding phenotype information;
applying, by at least one of the one or more computing devices, the phenotype prediction model to a plurality of available genotypes corresponding to the one or more of constrains to generate a plurality of scores, the phenotype prediction model being configured to predict one or more phenotypic attributes of the plurality of available genotypes;
determining, by at least one of the one or more computing devices, a plurality of result genotypes based at least in part on a ranking of the plurality of available genotypes according to the plurality of scores; and
generating, by at least one of the one or more computing devices, a result based at least in part on the plurality of result genotypes, the result indicating one or more genetic constructs for testing.