US 12,292,406 B2
Device for detecting analytes in a sample, and methods of use thereof
Shofarul Wustoni, Thuwal (SA); and Sahika Inal, Thuwal (SA)
Assigned to KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY, Thuwal (SA)
Appl. No. 17/632,613
Filed by King Abdullah University of Science and Technology, Thuwal (SA)
PCT Filed Aug. 3, 2020, PCT No. PCT/IB2020/057339
§ 371(c)(1), (2) Date Feb. 3, 2022,
PCT Pub. No. WO2021/024168, PCT Pub. Date Feb. 11, 2021.
Claims priority of provisional application 62/985,015, filed on Mar. 4, 2020.
Claims priority of provisional application 62/882,481, filed on Aug. 3, 2019.
Prior Publication US 2022/0283116 A1, Sep. 8, 2022
Int. Cl. G01N 27/414 (2006.01); G01N 27/31 (2006.01); G01N 27/327 (2006.01); G01N 27/333 (2006.01); G01N 27/447 (2006.01)
CPC G01N 27/4145 (2013.01) [G01N 27/31 (2013.01); G01N 27/327 (2013.01); G01N 27/3335 (2013.01); G01N 27/44726 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A device for detecting an analyte in a sample suspected of containing the analyte, comprising:
(a) a bio-functional nanostructured isoporous membranes (BNIM), and
(b) an organic electrochemical transistor (OECT),
wherein the OECT comprises:
(i) a source electrode,
(ii) a drain electrode,
(iii) a channel, and
(iv) a gate electrode,
wherein the BNIM comprises a binding partner specific for the analyte and an isoporous surface further comprising a pore size distribution,
wherein the source and drain electrodes are electrically connected by the channel, and
wherein the BNIM is placed above the channel and in contact with the source and drain electrodes.