US 12,292,399 B2
Highly selective chromatography-molecular rotational resonance spectroscopy systems and methods
Justin L. Neill, Charlottesville, VA (US); Matt Muckle, Earlysville, VA (US); Alexander V. Mikhonin, Charlottesville, VA (US); Walter H. Colsman, Weston, MA (US); and Daniel W. Armstrong, Arlington, TX (US)
Assigned to BrightSpec, Inc., Charlottesville, VA (US)
Appl. No. 17/609,246
Filed by BrightSpec, Inc., Charlottesville, VA (US)
PCT Filed May 7, 2020, PCT No. PCT/US2020/031890
§ 371(c)(1), (2) Date Nov. 5, 2021,
PCT Pub. No. WO2020/227541, PCT Pub. Date Nov. 12, 2020.
Claims priority of provisional application 62/977,846, filed on Feb. 18, 2020.
Claims priority of provisional application 62/913,082, filed on Oct. 9, 2019.
Claims priority of provisional application 62/844,280, filed on May 7, 2019.
Prior Publication US 2022/0196582 A1, Jun. 23, 2022
Int. Cl. G01N 23/2258 (2018.01); G01N 30/02 (2006.01); G01N 30/72 (2006.01)
CPC G01N 23/2258 (2013.01) [G01N 30/72 (2013.01); G01N 2030/027 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A system comprising:
a chromatograph to separate an analyte into components, wherein the components include co-eluting components that cannot be separated with the chromatograph;
a molecular rotational resonance (MRR) spectrometer, in fluid communication with the chromatograph, to measure MRR spectra of the components; and
a processor, operably coupled to the MRR spectrometer, to resolve, based at least in part on at least one of the MRR spectra, at least one of an isomer, an isotopologue, or an isotopomer among the components of the analyte and to form a total molecular chromatogram of the analyte based at least in part on the MRR spectra of the components.