US 12,292,380 B2
Integrated microfluidic device for capture and spectroscopic characterization of live cells under various treatment conditions
Gennady Shvets, Ithaca, NY (US); Glen Kelp, Ithaca, NY (US); and He Huang, Ithaca, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Appl. No. 17/262,347
Filed by CORNELL UNIVERSITY, Ithaca, NY (US)
PCT Filed Jul. 25, 2019, PCT No. PCT/US2019/043439
§ 371(c)(1), (2) Date Jan. 22, 2021,
PCT Pub. No. WO2020/023747, PCT Pub. Date Jan. 30, 2020.
Claims priority of provisional application 62/702,963, filed on Jul. 25, 2018.
Prior Publication US 2021/0302312 A1, Sep. 30, 2021
Int. Cl. G01N 21/552 (2014.01); B01L 3/00 (2006.01); G01N 21/35 (2014.01); G02B 5/00 (2006.01); G02B 21/06 (2006.01); G02B 21/36 (2006.01)
CPC G01N 21/554 (2013.01) [B01L 3/502715 (2013.01); G01N 21/35 (2013.01); G02B 5/008 (2013.01); G02B 21/06 (2013.01); B01L 2300/0663 (2013.01); G02B 21/36 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A detection unit, comprising:
a first layer comprising an IR-transparent substrate having a first side and a second side;
a second layer comprising a plasmonic metasurface having a first side and a second side, the first side of the plasmonic metasurface being disposed directly adjacent at least a portion of the second side of the IR-transparent substrate, the plasmonic metasurface comprising an array of metallic plasmonic conductive elements;
a holding component configured to hold the IR-transparent substrate; and
a channel to hold a fluid, wherein the channel is under the first layer and the second layer and above at least a portion of the holding component,
wherein the IR-transparent substrate of the first layer and the plasmonic metasurface of the second layer comprise different materials,
wherein the IR-transparent substrate is configured to transmit an IR incident light from the first side of the IR-transparent substrate to the second side of the IR-transparent substrate and to transmit an IR reflective light reflected by the plasmonic metasurface from the second side of the IR-transparent substrate to the first side of the IR-transparent substrate,
wherein the second layer is configured to reflect a first portion of IR light by the plasmonic metasurface back to the IR-transparent substrate and to transmit a second portion of the IR light;
wherein the detection unit is configured to output for analysis reflectance spectra corresponding only to the first portion of the IR light.