US 12,292,360 B2
Preliminary diagnoses of cut tissue sections
Partha P. Mitra, New York, NY (US); Charles R. Cantor, Del Mar, CA (US); Baris Yagci, Montclair, NY (US); and Steven Smith, Hawthorne, NY (US)
Assigned to Clarapath, Inc.
Filed by Clarapath, Inc., Hawthorne, NY (US)
Filed on Oct. 26, 2023, as Appl. No. 18/384,299.
Application 18/384,299 is a continuation of application No. 17/451,987, filed on Oct. 22, 2021, granted, now 11,959,835.
Claims priority of provisional application 63/104,907, filed on Oct. 23, 2020.
Prior Publication US 2024/0167917 A1, May 23, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 1/06 (2006.01); G01N 1/31 (2006.01); G02B 21/06 (2006.01); G02B 21/26 (2006.01); G02B 21/36 (2006.01); G06T 7/00 (2017.01)
CPC G01N 1/06 (2013.01) [G01N 1/312 (2013.01); G02B 21/06 (2013.01); G02B 21/26 (2013.01); G02B 21/365 (2013.01); G06T 7/0012 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/30024 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A system for optical interrogation of tissue samples, the system comprising:
a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections comprising one or more tissue samples;
an illumination system configured to illuminate the one or more tissue sections to optically stain the one or more tissue sections;
an imaging system configured to obtain imaging data on the one or more tissue sections illuminated with the illumination system; and
a processor being programmed to;
perform an imaging analysis of the imaging data to determine a presence or an absence of a disease in the one or more tissue sections illuminated with the illumination system; and
instruct the microtome to section one or more additional tissue sections for staining and imaging from the tissue block if there is a presence of the disease in the one or more tissue sections.