US 12,291,714 B2
Modulating reducing sugar content in a plant (INV)
Lucien Bovet, La Chaux-de-Fonds (CH); and Aurore Hilfiker, Salavaux (CH)
Assigned to Philip Morris Products S.A., Neuchatel (CH)
Appl. No. 17/765,748
Filed by PHILIP MORRIS PRODUCTS S.A., Neuchatel (CH)
PCT Filed Sep. 28, 2020, PCT No. PCT/EP2020/077048
§ 371(c)(1), (2) Date Mar. 31, 2022,
PCT Pub. No. WO2021/063860, PCT Pub. Date Apr. 8, 2021.
Claims priority of application No. 19200865 (EP), filed on Oct. 1, 2019.
Prior Publication US 2022/0348944 A1, Nov. 3, 2022
Int. Cl. C12N 15/82 (2006.01); C12N 9/26 (2006.01)
CPC C12N 15/8245 (2013.01) [C12N 9/2431 (2013.01); C12N 15/8213 (2013.01); C12N 15/8218 (2013.01); C12Y 302/01026 (2013.01)] 18 Claims
 
1. A Nicotiana tabacum plant cell comprising a non-natural modification to reduce expression or activity of one or both of a polynucleotide having at least 95% sequence identity to SEQ ID NO:5 and a polynucleotide having at least 95% sequence identity to SEQ ID NO:7, as compared to a control plant cell in which the plant cell has not been modified to modulate expression or activity of the one or both polynucleotides.