US 12,291,699 B2
Lung disease models on a chip
Dongeun Huh, Villanova, PA (US); Mark Mondrinos, Philadelphia, PA (US); and Woo Yul Byun, Richland, WA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Oct. 11, 2023, as Appl. No. 18/484,728.
Application 18/484,728 is a continuation of application No. 15/748,039, granted, now 11,814,613, previously published as PCT/US2016/044282, filed on Jul. 27, 2016.
Claims priority of provisional application 62/348,055, filed on Jun. 9, 2016.
Claims priority of provisional application 62/348,036, filed on Jun. 9, 2016.
Claims priority of provisional application 62/197,444, filed on Jul. 27, 2015.
Prior Publication US 2024/0218306 A1, Jul. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12M 3/00 (2006.01); A61L 27/18 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01); C08L 83/04 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12M 3/06 (2006.01); C12N 5/00 (2006.01); G01N 33/50 (2006.01); G09B 23/30 (2006.01)
CPC C12M 21/08 (2013.01) [A61L 27/18 (2013.01); A61L 27/22 (2013.01); A61L 27/3633 (2013.01); A61L 27/3804 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); C08L 83/04 (2013.01); C12M 3/00 (2013.01); C12M 23/00 (2013.01); C12M 23/16 (2013.01); C12M 23/20 (2013.01); C12M 25/02 (2013.01); C12M 25/14 (2013.01); C12M 29/10 (2013.01); C12N 5/0018 (2013.01); C12N 5/0062 (2013.01); C12N 5/0068 (2013.01); G01N 33/5005 (2013.01); G01N 33/5044 (2013.01); G09B 23/30 (2013.01); G09B 23/306 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01); C12N 2535/00 (2013.01); C12N 2537/10 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A biomimetic lung model, comprising:
a body having a first microchannel and a second microchannel disposed therein;
a membrane disposed between the first microchannel and the second microchannel, the membrane having a first side facing the first microchannel and a second side facing the second microchannel;
a layer of cells coating the first side of the membrane; and
tissue or cells embedded within a gel layer attached to the second side of the membrane,
wherein the layer of cells comprises airway epithelial cells.