US 12,291,618 B2
Method for producing a hydrophilic surface on PS/DVB copolymer particles
Andreas Seubert, Marburg (DE); Jonathan Sebastian Tripp, Marburg (DE); Rudolf Aeschlimann, Urnäsch (CH); Michael Ott, Thalheim an der Thur (CH); and Bastian Brand, Siebnen (CH)
Assigned to Metrohm AG, Herisau (CH)
Appl. No. 17/601,766
Filed by METROHM AG, Herisau (CH)
PCT Filed Apr. 7, 2020, PCT No. PCT/EP2020/059908
§ 371(c)(1), (2) Date Oct. 6, 2021,
PCT Pub. No. WO2020/208026, PCT Pub. Date Oct. 15, 2020.
Claims priority of application No. 19168303 (EP), filed on Apr. 10, 2019.
Prior Publication US 2022/0204712 A1, Jun. 30, 2022
Int. Cl. C08J 7/056 (2020.01); B01D 15/36 (2006.01); B01J 39/20 (2006.01); B01J 39/26 (2006.01); B01J 41/14 (2006.01); B01J 41/20 (2006.01); B01J 47/02 (2017.01); C08J 7/12 (2006.01)
CPC C08J 7/056 (2020.01) [B01D 15/361 (2013.01); B01J 39/20 (2013.01); B01J 39/26 (2013.01); B01J 41/14 (2013.01); B01J 41/20 (2013.01); B01J 47/02 (2013.01); C08J 7/12 (2013.01); C08J 2325/08 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method of modifying a polymeric support material for use as a stationary phase in an analytical or preparative separation process, the method comprising the steps of:
a. providing a polymeric carrier material at least partially formed from aromatic hydrocarbon compounds having at least two vinyl or allyl substituents;
b. generating hydroxy groups on/in the polymeric support material by a process comprising the steps of
b.1 oxidative treatment of the polymer carrier material, and subsequently
b.2 reductive or hydrolytic treatment of the reaction product of step b.1;
c. reacting the product of step b.2. with a polyfunctional compound comprising
at least a first functional group reactive with hydroxy groups, and
at least one second functional group reactive with at least one of amines and hydroxy groups.