US 12,291,600 B2
Three-dimensional spherical alpha-helix cationic polypeptide having high-efficiency gene delivery capability, and preparation method and application thereof
Lichen Yin, Suzhou (CN); Huan Ye, Suzhou (CN); and Rongying Zhu, Suzhou (CN)
Assigned to SOOCHOW UNIVERSITY, Suzhou (CN)
Appl. No. 17/797,398
Filed by SOOCHOW UNIVERSITY, Suzhou (CN)
PCT Filed Sep. 29, 2020, PCT No. PCT/CN2020/119113
§ 371(c)(1), (2) Date Aug. 3, 2022,
PCT Pub. No. WO2021/037281, PCT Pub. Date Mar. 4, 2021.
Claims priority of application No. 201910817961.4 (CN), filed on Aug. 30, 2019.
Prior Publication US 2023/0094088 A1, Mar. 30, 2023
Int. Cl. C08G 69/48 (2006.01); A61K 9/51 (2006.01); C08G 69/16 (2006.01)
CPC C08G 69/48 (2013.01) [A61K 9/5146 (2013.01); C08G 69/16 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A three-dimensional spherical α-helical polypeptide with high gene delivery efficiency, having a chemical structure of Formula (1):

OG Complex Work Unit Chemistry
in Formula (I), R1 is a dendrimer polyacrylamide unit selected from the group consisting of:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
R2 is N-carboxylic anhydride monomer unit,
R3 is an electrical small molecular unit selected from the group consisting of

OG Complex Work Unit Chemistry
wherein m is from 1 to 6, and
wherein n is from 20 to 200.