US 12,291,583 B2
Carrageenan derivative, probe for labelling macrophages, and method for preparing same
Hong Seog Seo, Seoul (KR); Yong Jik Lee, Incheon (KR); Jae Min Jeong, Seoul (KR); Yun Sang Lee, Gyeonggi-do (KR); and Ji Yong Park, Incheon (KR)
Assigned to KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, Seoul (KR); and SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR)
Appl. No. 17/439,177
Filed by KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, Seoul (KR); and SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR)
PCT Filed Mar. 13, 2020, PCT No. PCT/KR2020/003550
§ 371(c)(1), (2) Date Sep. 14, 2021,
PCT Pub. No. WO2020/185042, PCT Pub. Date Sep. 17, 2020.
Claims priority of application No. 10-2019-0029255 (KR), filed on Mar. 14, 2019; and application No. 10-2020-0031088 (KR), filed on Mar. 13, 2020.
Prior Publication US 2022/0162347 A1, May 26, 2022
Int. Cl. C08B 37/00 (2006.01); G01N 33/58 (2006.01)
CPC C08B 37/00 (2013.01) [G01N 33/58 (2013.01)] 17 Claims
 
1. A carrageenan derivative formed as a hydroxy group of a galactose or 3,6-anhydrogalactose moiety of carrageenan having a repeat unit represented by Chemical Formula 1 is oxidized to an aldehyde group through periodate oxidation, and
the aldehyde group is substituted with a compound represented by Chemical Formula 2 or Chemical Formula 3 and then reduced:

OG Complex Work Unit Chemistry
wherein
each of R1 to R4, which are identical to or different from each other, is any one selected from the group consisting of —H, —OH, —CH3, —CH2OH, —COOH, and —OSO3−,
R5 is any one selected from the group consisting of —H, —OH, —CH3, —CH2OH, —COOH, —CH2OSO3−, and —OSO3−,
n is an integer from 1 to 10,000, and
o is an integer from 1 to 10.